Original Article

The Role of Endoplasmic Reticulum Stress in Gastroesophageal Reflux Disease Symptoms and Treatment

Volume 34 · Issue 5 Publish Date: May 15, 2023
Elmas Kasap Tahir Buran Aysun Toraman Avcu Pınar Solmaz Hasdemir Erdal Balcan Çağdaş Aktan Mehmet Korkmaz
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Turkish Journal of Gastroenterology

Volume 34 · Issue 5

Pages: 533-541

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Published Online: May 15, 2023

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This work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright © 2023 Elmas Kasap, Tahir Buran, Aysun Toraman Avcu, Pınar Solmaz Hasdemir, Erdal Balcan, Çağdaş Aktan, Mehmet Korkmaz

Elmas Kasap
Departments of Gastroenterology and Pathology, Celal Bayar University School of Medicine, Manisa
Tahir Buran
Atatürk Teaching and Research Hospital, Department of Gastroenterology, izmir
Aysun Toraman Avcu
Department of Medical Biology Manisa Celal Bayar University Faculty of Medicine Manisa Turkey
Pınar Solmaz Hasdemir
Department of Medical Biology Manisa Celal Bayar University Faculty of Medicine Manisa Turkey
Erdal Balcan
Division of Biology, Department of Molecular Biology, Manisa Celal Bayar University Faculty of Arts and Science, Manisa, Turkey
Çağdaş Aktan
Department of Medical Biology, Ege University Faculty of Medicine, İzmir, Turkey
Mehmet Korkmaz
Department of Medical Biology, Manisa Celal Bayar University Faculty of Medicine, Manisa, Turkey
Kasap, E., Buran, T., Toraman Avcu, A., Solmaz Hasdemir, P., Balcan, E., Aktan, Çağdaş, & Korkmaz, M. (2023). The Role of Endoplasmic Reticulum Stress in Gastroesophageal Reflux Disease Symptoms and Treatment. Turkish Journal of Gastroenterology, 34(5), 533–541. https://doi.org/10.5152/tjg.2023.21282
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Abstract

Background: Gastroesophageal reflux disease is a common condition worldwide. There is no curative treatment for gastroesophageal reflux disease. Endoplasmic reticulum stress leads to the activation of the unfolded protein response and has an important role in inflammation. The aim is to determine the role of endoplasmic reticulum stress in the follow-up of individuals with gastroesophageal reflux disease and the temporal changes of endoplasmic reticulum stress markers with treatment. Methods: Twenty-four subjects in total were recruited prospectively, of whom 15 had nonerosive reflux disease. Two biopsies from 2 cm above the esophagogastric junction, 2 biopsies from gastric antrum mucosa, and 2 biopsies from gastric corpus mucosa were taken. Simultaneously, 2 tubes of venous blood samples were drawn from each individual (1 tube for studying the genetic markers and 1 tube for analyzing the CYP2C19 polymorphism). Results: The mean age was 42.3 ± 17.6 for women and 34.66 ± 11.2 for men. Pantoprazole, esomeprazole, rabeprazole, and lansoprazole preparations were used for treatment. There was no significant difference between tissue and blood samples for panel genes ATF-6, XBP-1, DDIT-3, DNAJC-10, and EIF-2-AK before treatment. There was a significant decrease in the level of ATF-6, XBP-1, DNAJC-9, EIF2-AK, and NF-2L-2 genes in blood after treatment. In the comparison of proton pump inhibitors, significant decreases in the expression of the ATF-6, XBP-1, and DNAJC-9 mRNAs were detected in blood from individuals after treatment. Conclusion: Endoplasmic reticulum stress can be for evaluating the clinical improvement and the effectiveness of treatment in gastroesophageal reflux disease. Cite this article as: Kasap E, Buran T, Toraman Avcu A, et al. The role of endoplasmic reticulum stress in gastroesophageal reflux disease symptoms and treatment. Turk J Gastroenterol. 2023;34(5):533-541.

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Article Info
Published In
Journal Turkish Journal of Gastroenterology
Volume / Issue Volume 34 · Issue 5
Pages 533-541
DOI 10.5152/tjg.2023.21282
History
Published Online May 15, 2023
License
Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright
Copyright (c) 2023 Elmas Kasap, Tahir Buran, Aysun Toraman Avcu, Pınar Solmaz Hasdemir, Erdal Balcan, Çağdaş Aktan, Mehmet Korkmaz
Affiliations
Elmas Kasap
Departments of Gastroenterology and Pathology, Celal Bayar University School of Medicine, Manisa
Tahir Buran
Atatürk Teaching and Research Hospital, Department of Gastroenterology, izmir
Aysun Toraman Avcu
Department of Medical Biology Manisa Celal Bayar University Faculty of Medicine Manisa Turkey
Pınar Solmaz Hasdemir
Department of Medical Biology Manisa Celal Bayar University Faculty of Medicine Manisa Turkey
Erdal Balcan
Division of Biology, Department of Molecular Biology, Manisa Celal Bayar University Faculty of Arts and Science, Manisa, Turkey
Çağdaş Aktan
Department of Medical Biology, Ege University Faculty of Medicine, İzmir, Turkey
Mehmet Korkmaz
Department of Medical Biology, Manisa Celal Bayar University Faculty of Medicine, Manisa, Turkey
Cite this Article
Kasap, E., Buran, T., Toraman Avcu, A., Solmaz Hasdemir, P., Balcan, E., Aktan, Çağdaş, & Korkmaz, M. (2023). The Role of Endoplasmic Reticulum Stress in Gastroesophageal Reflux Disease Symptoms and Treatment. Turkish Journal of Gastroenterology, 34(5), 533–541. https://doi.org/10.5152/tjg.2023.21282
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