Published In
Turkish Journal of Gastroenterology
Volume 26 · Issue 6
Pages: 522-527
History
Published Online: November 15, 2015
Copyright © 2015 Nevin Oruç, Ahmet Aydın, Burcu Barutcuoğlu, Çağdaş Aktan, Deniz Nart, Ali Veral
Nevin Oruç
Department of Gastroenterology, Ege University Faculty of Medicine, İzmir, Turkey
Ahmet Aydın
İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi Çocuk Sağlığı ve Hastalıkları anabilim Dalı, İstanbul
Burcu Barutcuoğlu
Department of Clinical Biochemistry, Ege University Faculty of Medicine, İzmir, Turkey
Çağdaş Aktan
Department of Medical Biology, Ege University Faculty of Medicine, İzmir, Turkey
Deniz Nart
Departments of Pathology, Ege University School of Medicine, İzmir
Ali Veral
Department of Pathology, Ege University Faculty of Medicine, İzmir, Turkey
Oruç, N., Aydın, A., Barutcuoğlu, B., Aktan, Çağdaş, Nart, D., & Veral, A. (2015). Cystic fluid chromogranin A levels in different pancreatic cystic lesions. Turkish Journal of Gastroenterology, 26(6), 522–527. https://doi.org/10.5152/tjg.2015.0329
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Abstract
Abstract Background/Aims: Pancreatic cystic lesions have a broad spectrum of differential diagnosis. There is an ongoing demand to identify specific and sensitive cystic fluid markers for the differential diagnosis of pancreatic cysts. We aimed to evaluate the diagnostic value of cystic fluid chromogranin A (CgA) in the differential diagnosis of pancreatic cysts. Materials and Methods: Patients who underwent endoscopic ultrasound (EUS)-guided aspiration for pancreatic cysts were included in the study. Cytopathological analysis and biochemical analysis, including cystic fluid carcinoembryonic antigen (CEA), amylase, Ca 19-9, and CgA, were performed. Results: Fifty-three patients were included in the study. The final diagnosis of patients was 14 pancreatic pseudocysts, 10 intraductal papillary mucinous neoplasms (IPMNs), 8 mucinous cystic neoplasms (MCN), 8 serous cystadenomas (SCAs), 2 cystic pancreatic neuroendocrine tumors (PNETs), and 11 others. The mean CgA levels were 50.51±130.04 ng/mL in pseudocysts, 12.38±8.59 in MCN, and 13.76±10.90 in cystic PNET. There was only one patient with a very high cystic fluid CgA (515.49 ng/mL) and was diagnosed as pseudocyst developed in chronic pancreatitis patient. Two patients with cystic PNET had normal levels of cystic fluid CgA. Conclusion: Cystic fluid CgA is not a useful marker for the differential diagnosis of cystic PNETs. It also has no value in the differential diagnosis of other pancreatic cysts.
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Article Info
Published In
Journal
Turkish Journal of Gastroenterology
Volume / Issue
Volume 26 · Issue 6
Pages
522-527
History
Published Online
November 15, 2015
Copyright
Copyright (c) 2015 Nevin Oruç, Ahmet Aydın, Burcu Barutcuoğlu, Çağdaş Aktan, Deniz Nart, Ali Veral
Affiliations
Nevin Oruç
Department of Gastroenterology, Ege University Faculty of Medicine, İzmir, Turkey
Ahmet Aydın
İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi Çocuk Sağlığı ve Hastalıkları anabilim Dalı, İstanbul
Burcu Barutcuoğlu
Department of Clinical Biochemistry, Ege University Faculty of Medicine, İzmir, Turkey
Çağdaş Aktan
Department of Medical Biology, Ege University Faculty of Medicine, İzmir, Turkey
Deniz Nart
Departments of Pathology, Ege University School of Medicine, İzmir
Ali Veral
Department of Pathology, Ege University Faculty of Medicine, İzmir, Turkey
Cite this Article
Oruç, N., Aydın, A., Barutcuoğlu, B., Aktan, Çağdaş, Nart, D., & Veral, A. (2015). Cystic fluid chromogranin A levels in different pancreatic cystic lesions. Turkish Journal of Gastroenterology, 26(6), 522–527. https://doi.org/10.5152/tjg.2015.0329
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