Gastrointestinal Tract - Original Article

Potential role of chromatin remodeling factor genes in atrophic gastritis/gastric cancer risk

Volume 29 · Issue 4 Publish Date: July 15, 2018
Fahri Bilgiç Emre Gerçeker Seda Örenay Boyacıoğlu Elmas Kasap Ufuk Demirci Hatice Yıldırım Ahmed Ramiz Baykan Hakan Yüceyar
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Turkish Journal of Gastroenterology

Volume 29 · Issue 4

Pages: 427-435

History

Published Online: July 15, 2018

Copyright © 2018 Fahri Bilgiç, Emre Gerçeker, Seda Örenay Boyacıoğlu, Elmas Kasap, Ufuk Demirci, Hatice Yıldırım, Ahmed Ramiz Baykan, Hakan Yüceyar

Fahri Bilgiç
Department of Internal Medicine, Celal Bayar University School of Medicine, Manisa, Turkey
Emre Gerçeker
Department of Gastroenterology, Gazi Hospital, İzmir, Turkey
Seda Örenay Boyacıoğlu
Department of Medical Genetics, Adnan Menderes University School of Medicine, Aydın, Turkey
Elmas Kasap
Departments of Gastroenterology and Pathology, Celal Bayar University School of Medicine, Manisa
Ufuk Demirci
Department of Internal Medicine, Celal Bayar University School of Medicine, Manisa, Turkey
Hatice Yıldırım
Department of Medical Biology, Celal Bayar University School of Medicine, Manisa, Turkey
Ahmed Ramiz Baykan
Department of Gastroenterology, Erzurum Regional Training and Research Hospital, Erzurum, Turkey
Hakan Yüceyar
Ege Üniversitesi Tıp Fakültesi, Namık Kemal Menteş Gastroenteroloji Kliniği, İzmir
Bilgiç, F., Gerçeker, E., Örenay Boyacıoğlu, S., Kasap, E., Demirci, U., Yıldırım, H., … Yüceyar, H. (2018). Potential role of chromatin remodeling factor genes in atrophic gastritis/gastric cancer risk. Turkish Journal of Gastroenterology, 29(4), 427–435. https://doi.org/10.5152/tjg.2018.17350
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Abstract

Abstract Background/Aims: Atrophic gastritis (AG), intestinal metaplasia (IM), and Helicobacter pylori (HP) are the risk factors for the development of gastric cancer (GC). Chromatin remodeling is one of the epigenetic mechanisms involved in the carcinogenesis of GC. The purpose of this study was to investigate the expression profiles of defined chromatin remodeling genes in gastric mucosal samples and their values as gastric carcinogenesis biomarkers. Materials and Methods: In total, 95 patients were included in the study. Patients were divided into 3 groups as: GC group (n=34), AG group (n=36), and control group (n=25). AG group was further divided into subgroups based on the presence of HP and IM in gastric mucosa. Chromatin remodeling gene expressions were analyzed using real-time PCR (RT-PCR) array in all groups. Data were evaluated using the RT-qPCR primer assay data analysis software. Results: EED, CBX3, and MTA1 were more overexpressed, whereas ARID1A, ING5, and CBX7 were more underexpressed in the AG and GC groups compared with the controls. No significant differences were observed between the AG and GC groups concerning the expression of these 6 genes, although the fold change levels of these genes in the GC group were well above than in the AG group. EED, CBX3, and MTA1 were significantly more overexpressed in HP- and IM-positive AG subgroup compared with the HP- or IM-negative AG subgroup. Conclusion: In conclusion, our results provide an evidence of epigenetic alterations in AG. Expressions of EED, CBX3, MTA1, ARID1A, ING5, and CBX7 may be considered as promising markers to be used in GC screening for patients with AG. Cite this article as: Bilgiç F, Gerçeker E, Örenay Boyacıoğlu S, et al. Potential role of chromatin remodeling factor genes in atrophic gastritis/gastric cancer risk. Turk J Gastroenterol 2018; 29: 427-35.

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Article Info
Published In
Journal Turkish Journal of Gastroenterology
Volume / Issue Volume 29 · Issue 4
Pages 427-435
DOI 10.5152/tjg.2018.17350
History
Published Online July 15, 2018
Copyright
Copyright (c) 2018 Fahri Bilgiç, Emre Gerçeker, Seda Örenay Boyacıoğlu, Elmas Kasap, Ufuk Demirci, Hatice Yıldırım, Ahmed Ramiz Baykan, Hakan Yüceyar
Affiliations
Fahri Bilgiç
Department of Internal Medicine, Celal Bayar University School of Medicine, Manisa, Turkey
Emre Gerçeker
Department of Gastroenterology, Gazi Hospital, İzmir, Turkey
Seda Örenay Boyacıoğlu
Department of Medical Genetics, Adnan Menderes University School of Medicine, Aydın, Turkey
Elmas Kasap
Departments of Gastroenterology and Pathology, Celal Bayar University School of Medicine, Manisa
Ufuk Demirci
Department of Internal Medicine, Celal Bayar University School of Medicine, Manisa, Turkey
Hatice Yıldırım
Department of Medical Biology, Celal Bayar University School of Medicine, Manisa, Turkey
Ahmed Ramiz Baykan
Department of Gastroenterology, Erzurum Regional Training and Research Hospital, Erzurum, Turkey
Hakan Yüceyar
Ege Üniversitesi Tıp Fakültesi, Namık Kemal Menteş Gastroenteroloji Kliniği, İzmir
Cite this Article
Bilgiç, F., Gerçeker, E., Örenay Boyacıoğlu, S., Kasap, E., Demirci, U., Yıldırım, H., … Yüceyar, H. (2018). Potential role of chromatin remodeling factor genes in atrophic gastritis/gastric cancer risk. Turkish Journal of Gastroenterology, 29(4), 427–435. https://doi.org/10.5152/tjg.2018.17350
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