Published In
Turkish Journal of Gastroenterology
Volume 29 · Issue 4
Pages: 464-472
History
Published Online: July 15, 2018
Copyright © 2018 İftihar Köksal, Gürdal Yılmaz, Mehmet Parlak, Tuna Demirdal, Sami Kınıklı, Mehmet Candan, Ali Kaya, Sıla Akhan, Özcan Aydoğdu, Hüseyin Turgut, Yunus Gürbüz, Özgür Dağlı, Ahmet Ali Gökal, Rahmet Güner, Ziya Kuruüzüm, Hüseyin Tarakçı, Nuri Beslen, Seda Erdoğan, Fatih Özdener, The Chronic Hepatitis C Study Group
İftihar Köksal
KTÜ Tıp Fakültesi İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı, Trabzon
Gürdal Yılmaz
Department of Infectious Diseases, Karadeniz Technical University School of Medicine, Trabzon, Turkey
Mehmet Parlak
Department of Clinical Microbiology, Yüzüncü Yıl University, School of Medicine, Van
Tuna Demirdal
Departments of Infectious Diseases and Clinical Microbiology, Afyon Kocatepe University School of Medicine, Afyon
Sami Kınıklı
Ministry of Health Ankara Hospital, Ankara
Mehmet Candan
Department of Infectious Diseaes, 25 Aralık State Hospital, Gaziantep, Turkey
Ali Kaya
Department of Infectious Diseaes, Mersin University School of Medicine, Mersin, Turkey
Sıla Akhan
Department of Infectious Diseaes, Kocaeli, University School of Medicine, Kocaeli, Turkey
Özcan Aydoğdu
Department of Infectious Diseaes, Bafra State Hospital, Samsun, Turkey
Hüseyin Turgut
Department of Infectious Diseaes, Pamukkale University School of Medicine, Denizli, Turkey
Yunus Gürbüz
Department of Infectious Diseaes, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey
Özgür Dağlı
Department of Infectious Diseaes, Kilis State Hospital, Kilis, Turkey
Ahmet Ali Gökal
Department of Infectious Diseaes, Giresun A. İlhan Özdemir State Hospital, Giresun, Turkey
Rahmet Güner
Department of Infectious diseases, Yıldırım Beyazıt University Faculty of Medicine, Ankara, Turkey
Ziya Kuruüzüm
Department of Infectious Diseaes, Dokuz Eylül University School of Medicine, İzmir, Turkey
Hüseyin Tarakçı
Department of Infectious Diseaes, Eşrefpaşa State Hospital, İzmir, Turkey
Nuri Beslen
Department of Infectious Diseaes, Kayseri Training and Research Hospital, Kayseri, Turkey
Seda Erdoğan
Clinical Trials and Medical Department, Roche Pharmaceuticals, İstanbul, Turkey
Fatih Özdener
Clinical Trials and Medical Department, Roche Pharmaceuticals, İstanbul, Turkey
The Chronic Hepatitis C Study Group
The Chronic Hepatitis C Study Group
Köksal, İftihar, Yılmaz, G., Parlak, M., Demirdal, T., Kınıklı, S., Candan, M., … C Study Group, T. C. H. (2018). Diagnostic value of combined serum biomarkers for the evaluation of liver fibrosis in chronic hepatitis C infection: A multicenter, noninterventional, observational study. Turkish Journal of Gastroenterology, 29(4), 464–472. https://doi.org/10.5152/tjg.2018.16597
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Abstract
Abstract Background/Aims: The hepatitis C virus (HCV) infection is important cause of chronic hepatitis. Liver biopsy is considered the gold standard for assessment of fibrosis but this procedure is an invasive procedure. We aimed to evaluate the diagnostic efficiency of non-invasive serum biomarkers, separately and in combinations, on liver fibrosis in treatment-naive chronic hepatitis C (CHC) patients. Materials and Methods: Two hundred and sixteen treatment-naive CHC patients were enrolled from 32 locations across Turkey in this open-labelled, non-interventional prospective observational study. FibroTest®, aspartate aminotransferase-to-platelet ratio index(APRI), aspartate aminotransferase and alanine aminotransferase ratio (AAR), fibrosis index based on four factors (FIB-4), Age-platelet(AP) index and Forns index were measured and compared with Metavir scores got from liver biopsies. Results: Data from 182 patients with baseline liver biopsy were suitable for analysis. One hundred and twenty patients (65.9%) had F0-F1 fibrosis and 62 patients (34.1%) had F2-F4 fibrosis. APRI 0.732 area under the curve(AUC) indicated advanced fibrosis with 69% sensitivity and 77% specificity. FIB-4 0.732 AUC and FibroTest 0.715 AUC indicated advanced fibrosis with 69% and 78.4% sensitivity, and 75% and 71.4% specificity, respectively. The combined use of tests also led to an increase in AUC and specificity. Combinations of FibroTest with APRI and/or FIB-4, and FIB-4 with APRI were optimal for the evaluation of liver fibrosis. Conclusion: Fibrotest, FIB-4, APRI, AP index and Forns index exhibit good diagnostic performance for determining liver fibrosis in CHC patients, and the use of at least two tests together will increase their diagnostic value still further. Cite this article as: Köksal İ, Yılmaz G, Parlak M, et al. Diagnostic value of combined serum biomarkers for the evaluation of liver fibrosis in chronic hepatitis C infection: A multicenter, noninterventional, observational study. Turk J Gastroenterol 2018; 29: 464-72.
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Article Info
Published In
Journal
Turkish Journal of Gastroenterology
Volume / Issue
Volume 29 · Issue 4
Pages
464-472
History
Published Online
July 15, 2018
Copyright
Copyright (c) 2018 İftihar Köksal, Gürdal Yılmaz, Mehmet Parlak, Tuna Demirdal, Sami Kınıklı, Mehmet Candan, Ali Kaya, Sıla Akhan, Özcan Aydoğdu, Hüseyin Turgut, Yunus Gürbüz, Özgür Dağlı, Ahmet Ali Gökal, Rahmet Güner, Ziya Kuruüzüm, Hüseyin Tarakçı, Nuri Beslen, Seda Erdoğan, Fatih Özdener, The Chronic Hepatitis C Study Group
Affiliations
İftihar Köksal
KTÜ Tıp Fakültesi İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı, Trabzon
Gürdal Yılmaz
Department of Infectious Diseases, Karadeniz Technical University School of Medicine, Trabzon, Turkey
Mehmet Parlak
Department of Clinical Microbiology, Yüzüncü Yıl University, School of Medicine, Van
Tuna Demirdal
Departments of Infectious Diseases and Clinical Microbiology, Afyon Kocatepe University School of Medicine, Afyon
Sami Kınıklı
Ministry of Health Ankara Hospital, Ankara
Mehmet Candan
Department of Infectious Diseaes, 25 Aralık State Hospital, Gaziantep, Turkey
Ali Kaya
Department of Infectious Diseaes, Mersin University School of Medicine, Mersin, Turkey
Sıla Akhan
Department of Infectious Diseaes, Kocaeli, University School of Medicine, Kocaeli, Turkey
Özcan Aydoğdu
Department of Infectious Diseaes, Bafra State Hospital, Samsun, Turkey
Hüseyin Turgut
Department of Infectious Diseaes, Pamukkale University School of Medicine, Denizli, Turkey
Yunus Gürbüz
Department of Infectious Diseaes, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey
Özgür Dağlı
Department of Infectious Diseaes, Kilis State Hospital, Kilis, Turkey
Ahmet Ali Gökal
Department of Infectious Diseaes, Giresun A. İlhan Özdemir State Hospital, Giresun, Turkey
Rahmet Güner
Department of Infectious diseases, Yıldırım Beyazıt University Faculty of Medicine, Ankara, Turkey
Ziya Kuruüzüm
Department of Infectious Diseaes, Dokuz Eylül University School of Medicine, İzmir, Turkey
Hüseyin Tarakçı
Department of Infectious Diseaes, Eşrefpaşa State Hospital, İzmir, Turkey
Nuri Beslen
Department of Infectious Diseaes, Kayseri Training and Research Hospital, Kayseri, Turkey
Seda Erdoğan
Clinical Trials and Medical Department, Roche Pharmaceuticals, İstanbul, Turkey
Fatih Özdener
Clinical Trials and Medical Department, Roche Pharmaceuticals, İstanbul, Turkey
The Chronic Hepatitis C Study Group
The Chronic Hepatitis C Study Group
Cite this Article
Köksal, İftihar, Yılmaz, G., Parlak, M., Demirdal, T., Kınıklı, S., Candan, M., … C Study Group, T. C. H. (2018). Diagnostic value of combined serum biomarkers for the evaluation of liver fibrosis in chronic hepatitis C infection: A multicenter, noninterventional, observational study. Turkish Journal of Gastroenterology, 29(4), 464–472. https://doi.org/10.5152/tjg.2018.16597
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