Published In
Turkish Journal of Gastroenterology
Volume 25 · Issue 5
Pages: 546-552
History
Published Online: October 15, 2014
Copyright © 2014 Abdulkadir Dökmeci, Yücel Üstündağ, Saadettin Hulagu, İlyas Tuncer, Meral Akdoğan, Hüseyin Demirsoy, Seyfettin Köklü, Fatih Güzelbulut, İbrahim Doğan, Ali Demir, Mesut Akarsu, Hakan Yüceyar, Osman Cavit Özdoğan, Fatih Özdener, Seda Erdoğan
Abdulkadir Dökmeci
Ankara Üniversitesi Tıp Fakültesi İç Hastalıkları A.B.D. Ankara
Yücel Üstündağ
Hacettepe University Medical School Departments of Internal Medicine Ankara, Turkey
Saadettin Hulagu
Department of Gastroenterology, Kocaeli University Faculty of Medicine, Kocaeli, Turkey
İlyas Tuncer
Departments of Gastroenterology and Internal Medicine, Göztepe Training and Research Hospital and Department of Pathology
Meral Akdoğan
Department of Gastroenterology, Türkiye Yüksek İhtisas Hospital, Ankara, Turkey
Hüseyin Demirsoy
Departments of Gastroenterology, Şişli Etfal Education and Research Hospital, İstanbul
Seyfettin Köklü
Department of Internal Medicine, Division of Gastroenterology, Hacettepe University Faculty of Medicine, Ankara, Turkey
Fatih Güzelbulut
Department of Gastroenterology, Haydarpaşa Training and Research Hospital, İstanbul, Turkey
İbrahim Doğan
Department of Gastroenterology, Gazi University School of Medicine, Ankara
Ali Demir
Division of Gastroenterology, Department of Internal Medicine, Meram School of Medicine, Necmettin Erbakan University, Meram, Konya, Turkey
Mesut Akarsu
Dokuz Eylül University, Faculty of Medicine, Division of Gastroenterology, İzmir, Turkey
Hakan Yüceyar
Ege Üniversitesi Tıp Fakültesi, Namık Kemal Menteş Gastroenteroloji Kliniği, İzmir
Osman Cavit Özdoğan
GATA Haydarpaşa Eğitim Hastanesi Gastroenteroloji Servisleri, İstanbul
Fatih Özdener
Clinical Trials and Medical Department, Roche Pharmaceuticals, İstanbul, Turkey
Seda Erdoğan
Clinical Trials and Medical Department, Roche Pharmaceuticals, İstanbul, Turkey
Dökmeci, A., Üstündağ, Y., Hulagu, S., Tuncer, İlyas, Akdoğan, M., Demirsoy, H., … Erdoğan, S. (2014). The association between insulin resistance and hepatic fibrosis in patients with chronic hepatitis C: An observational, multicenter study in Turkey. Turkish Journal of Gastroenterology, 25(5), 546–552. https://doi.org/10.5152/tjg.2014.7829
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Abstract
Abstract Background/Aims: To evaluate the association between insulin resistance and hepatic fibrosis in patients with chronic hepatitis C. Materials and Methods: A total of 104 chronic hepatitis C patients were included in this non-interventional, open-label, observational, multicenter, cross-sectional study conducted at 20 gastroenterology clinics in Turkey. The primary end point was the correlation between stage of hepatic fibrosis and insulin resistance evaluated via the homeostasis model of assessment-insulin resistance index. Confounders of hepatic fibrosis and insulin resistance were the secondary end points. Results: The mean age of patients was 52.8 years; 65.4% were female. Type 2 diabetes was present in 6.8% and insulin resistance noted in 38.0% of patients. Further, 45.7% of the patients had mild (A0/A1) and the remaining had moderate/severe (A2/A3) hepatic necroinflammatory activity. Patient distribution according to Metavir fibrosis stage was as follows: F0/F1 (57.0%); F2 (6.5%); F3 (23.7%); and F4 (12.9%). A univariate analysis revealed significant positive correlations between Metavir fibrosis stage and insulin resistance (r=0.297; p=0.007). Logistic regression analysis showed that significant predictors of insulin resistance were high alanine transaminase levels (odds ratio, 0.97; 95% confidence interval, 0.944-0.997) and liver fibrosis stage (odds ratio, 0.114; 95% confidence interval, 0.021-0.607). Conclusion: Our findings revealed significant associations between insulin resistance and hepatic fibrosis.
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Article Info
Published In
Journal
Turkish Journal of Gastroenterology
Volume / Issue
Volume 25 · Issue 5
Pages
546-552
History
Published Online
October 15, 2014
Copyright
Copyright (c) 2014 Abdulkadir Dökmeci, Yücel Üstündağ, Saadettin Hulagu, İlyas Tuncer, Meral Akdoğan, Hüseyin Demirsoy, Seyfettin Köklü, Fatih Güzelbulut, İbrahim Doğan, Ali Demir, Mesut Akarsu, Hakan Yüceyar, Osman Cavit Özdoğan, Fatih Özdener, Seda Erdoğan
Affiliations
Abdulkadir Dökmeci
Ankara Üniversitesi Tıp Fakültesi İç Hastalıkları A.B.D. Ankara
Yücel Üstündağ
Hacettepe University Medical School Departments of Internal Medicine Ankara, Turkey
Saadettin Hulagu
Department of Gastroenterology, Kocaeli University Faculty of Medicine, Kocaeli, Turkey
İlyas Tuncer
Departments of Gastroenterology and Internal Medicine, Göztepe Training and Research Hospital and Department of Pathology
Meral Akdoğan
Department of Gastroenterology, Türkiye Yüksek İhtisas Hospital, Ankara, Turkey
Hüseyin Demirsoy
Departments of Gastroenterology, Şişli Etfal Education and Research Hospital, İstanbul
Seyfettin Köklü
Department of Internal Medicine, Division of Gastroenterology, Hacettepe University Faculty of Medicine, Ankara, Turkey
Fatih Güzelbulut
Department of Gastroenterology, Haydarpaşa Training and Research Hospital, İstanbul, Turkey
İbrahim Doğan
Department of Gastroenterology, Gazi University School of Medicine, Ankara
Ali Demir
Division of Gastroenterology, Department of Internal Medicine, Meram School of Medicine, Necmettin Erbakan University, Meram, Konya, Turkey
Mesut Akarsu
Dokuz Eylül University, Faculty of Medicine, Division of Gastroenterology, İzmir, Turkey
Hakan Yüceyar
Ege Üniversitesi Tıp Fakültesi, Namık Kemal Menteş Gastroenteroloji Kliniği, İzmir
Osman Cavit Özdoğan
GATA Haydarpaşa Eğitim Hastanesi Gastroenteroloji Servisleri, İstanbul
Fatih Özdener
Clinical Trials and Medical Department, Roche Pharmaceuticals, İstanbul, Turkey
Seda Erdoğan
Clinical Trials and Medical Department, Roche Pharmaceuticals, İstanbul, Turkey
Cite this Article
Dökmeci, A., Üstündağ, Y., Hulagu, S., Tuncer, İlyas, Akdoğan, M., Demirsoy, H., … Erdoğan, S. (2014). The association between insulin resistance and hepatic fibrosis in patients with chronic hepatitis C: An observational, multicenter study in Turkey. Turkish Journal of Gastroenterology, 25(5), 546–552. https://doi.org/10.5152/tjg.2014.7829
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