Original Article

Tenofovir–best hope for treatment of chronic hepatitis B infection?

Volume 26 · Issue 4 Publish Date: July 15, 2015
Necati Örmeci Burak Özbaş Rahmet Güner Hasan Özkan Aysun Yalçı Şahin Çoban Abdülkadir Dökmeci Çağdaş Kalkan Hakan Akıncı Osman Yüksel Ömer Başar İlhami Yüksel İsmail Balık
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Turkish Journal of Gastroenterology

Volume 26 · Issue 4

Pages: 322-327

History

Published Online: July 15, 2015

Copyright © 2015 Necati Örmeci, Burak Özbaş, Rahmet Güner, Hasan Özkan, Aysun Yalçı, Şahin Çoban, Abdülkadir Dökmeci, Çağdaş Kalkan, Hakan Akıncı, Osman Yüksel, Ömer Başar, İlhami Yüksel, İsmail Balık

Necati Örmeci
Department of Gastroenterology, Ankara University School of Medicine, Ankara, Turkey
Burak Özbaş
Department of Internal Medicine, Ankara University Faculty of Medicine, Ankara, Turkey
Rahmet Güner
Department of Infectious diseases, Yıldırım Beyazıt University Faculty of Medicine, Ankara, Turkey
Hasan Özkan
Ankara Üniversitesi Tıp Fakültesi Gastroenteroloji Anabilim Dalı
Aysun Yalçı
Department of Infectious Diseases, Ankara University Faculty of Medicine, Ankara, Turkey
Şahin Çoban
Department of Gastroenterology, Dışkapı Yıldırım Beyazıt Education and Research Hospital, Ankara, Turkey
Abdülkadir Dökmeci
Ankara Üniversitesi Tıp Fakültesi Gastroenteroloji Bilim Dalı, Ankara
Çağdaş Kalkan
Department of Gastroenterology, Ankara University School of Medicine İbn-i Sina Hospital, Ankara, Turkey
Hakan Akıncı
Department of Gastroenterology, Dışkapı Yıldırım Beyazıt Education and Research Hospital, Ankara, Turkey
Osman Yüksel
Department of Gastroenterology, Hacettepe University Faculty of Medicine, Ankara, Turkey
Ömer Başar
Department of Gastroenterology, Hacettepe University Faculty of Medicine, Ankara, Turkey
İlhami Yüksel
Departments of Gastroenterology, Etlik İhtisas Educational and Research Hospital, Ankara
İsmail Balık
Department of Infectious diseases, Yıldırım Beyazıt University Faculty of Medicine, Ankara, Turkey
Örmeci, N., Özbaş, B., Güner, R., Özkan, H., Yalçı, A., Çoban, Şahin, … Balık, İsmail. (2015). Tenofovir–best hope for treatment of chronic hepatitis B infection?. Turkish Journal of Gastroenterology, 26(4), 322–327. https://doi.org/10.5152/tjg.2015.0164
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Abstract

Abstract Background/Aims: To evaluate the effectiveness of tenofovir in patients with chronic hepatitis B infection in a real life setting. Materials and Methods: We performed a retrospective analysis of data from 164 patients with chronic hepatitis B who were treated with Tenofovir. Eighty-six patients (52.4%) were naïve. Seventy-seven (46.9%) patients were previously treated with anti-viral drugs, including standard interferon (n=4), pegylated (PEG) interferon (n=14), standard interferon together with lamivudine (n=13), lamivudine alone (n=41), adefovir (n=2), lamivudine together with adefovir (n=1), and entecavir (n=2). Six patients (3.7%) had liver cirrhosis before treatment of tenofovir. Results: The patients who have hepatitis B viral DNA>104 copy/mL with chronic hepatitis B infection were included in the treatment of Tenofovir. Average follow up time was 30.31±14.33 months. HBV DNA negativity and alanine aminotransferase (ALT) normalization were 86.5% and 71.3%, respectively, at the last visit. Hepatitis B e-Antigen (HBeAg) seroconversion occurred in 11 (19.6%) out of 164 patients. During the follow-up period, 4 (2.4%) patients developed liver cirrhosis and in 5 (3%) patients hepatocellular carcinoma (HCC) occurred out of 164 patients. HBsAg seroconversion occurred in one patient (0.6%). Conclusion: Tenofovir can be used safely and successfully in those patients that were naive, experienced with immune modulators and/or antivirals, HBeAg-positive, and HBeAg-negative patients.

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Article Info
Published In
Journal Turkish Journal of Gastroenterology
Volume / Issue Volume 26 · Issue 4
Pages 322-327
DOI 10.5152/tjg.2015.0164
History
Published Online July 15, 2015
Copyright
Copyright (c) 2015 Necati Örmeci, Burak Özbaş, Rahmet Güner, Hasan Özkan, Aysun Yalçı, Şahin Çoban, Abdülkadir Dökmeci, Çağdaş Kalkan, Hakan Akıncı, Osman Yüksel, Ömer Başar, İlhami Yüksel, İsmail Balık
Affiliations
Necati Örmeci
Department of Gastroenterology, Ankara University School of Medicine, Ankara, Turkey
Burak Özbaş
Department of Internal Medicine, Ankara University Faculty of Medicine, Ankara, Turkey
Rahmet Güner
Department of Infectious diseases, Yıldırım Beyazıt University Faculty of Medicine, Ankara, Turkey
Hasan Özkan
Ankara Üniversitesi Tıp Fakültesi Gastroenteroloji Anabilim Dalı
Aysun Yalçı
Department of Infectious Diseases, Ankara University Faculty of Medicine, Ankara, Turkey
Şahin Çoban
Department of Gastroenterology, Dışkapı Yıldırım Beyazıt Education and Research Hospital, Ankara, Turkey
Abdülkadir Dökmeci
Ankara Üniversitesi Tıp Fakültesi Gastroenteroloji Bilim Dalı, Ankara
Çağdaş Kalkan
Department of Gastroenterology, Ankara University School of Medicine İbn-i Sina Hospital, Ankara, Turkey
Hakan Akıncı
Department of Gastroenterology, Dışkapı Yıldırım Beyazıt Education and Research Hospital, Ankara, Turkey
Osman Yüksel
Department of Gastroenterology, Hacettepe University Faculty of Medicine, Ankara, Turkey
Ömer Başar
Department of Gastroenterology, Hacettepe University Faculty of Medicine, Ankara, Turkey
İlhami Yüksel
Departments of Gastroenterology, Etlik İhtisas Educational and Research Hospital, Ankara
İsmail Balık
Department of Infectious diseases, Yıldırım Beyazıt University Faculty of Medicine, Ankara, Turkey
Cite this Article
Örmeci, N., Özbaş, B., Güner, R., Özkan, H., Yalçı, A., Çoban, Şahin, … Balık, İsmail. (2015). Tenofovir–best hope for treatment of chronic hepatitis B infection?. Turkish Journal of Gastroenterology, 26(4), 322–327. https://doi.org/10.5152/tjg.2015.0164
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