Turkish Journal of Gastroenterology
Original Article

Treatment Adherence of Anti-TNF Drugs in the Patients with Inflammatory Bowel Disease: A Scale Development Study


Internal Medicine Nursing Department, Institute of Health Science, İzmir Katip Çelebi University, İzmir, Turkey


Faculty of Health Science, İzmir Katip Çelebi University, İzmir, Turkey


İzmir Katip Çelebi University Medical School, İzmir, Turkey

Turk J Gastroenterol 2022; 33: 336-345
DOI: 10.5152/tjg.2022.211170
Read: 249 Downloads: 86 Published: 01 April 2022

Background: This work studies the validity and reliability of the Anti-TNF Alpha Treatment Adherence Scale, which has newly been developed to measure the compliance of inflammatory bowel disease patients using the anti-TNF alpha agents that are widely used in gastroenterology and rheumatology clinics.

Methods: The study group consisted of 165 irritable bowel disease patients aged 18 years and above who were using anti-TNF alpha drugs. After creating a question pool with 40 items, the pilot study was applied with 70 patients. SPSS 25.0 and AMOS programs were used. Item-total correlation coefficients, Cronbach’s alpha and test-retest analysis, missing data, extreme value, normality, 27% sub- upper item discrimination analysis, and exploratory and confirmatory factor analyses were used.

Results: The factor structure of the scale was examined with exploratory and confirmatory factor analyses and the contribution of these components to the total variance was measured as 74.21%. The Anti-TNF Alpha Treatment Adherence Scale was found in relation to the scale structure consisting of 12 items and 4 sub-dimensions. According to the first level multifactorial analysis results, the goodness of fit identities of the scale were found at an acceptable level, with the following values: RMSEA 0.067; GFI 0.92; AGFI 0.87; CFI 0.95; andχ2 79.876 (P = .000).

Conclusion: It was determined that the Anti-TNF Alpha Treatment Adherence Scale represents the area to be measured, measures the researched structure, has a high internal consistency between items, is interrelated, and is consistent over time. As a result of all mea- surements, it was determined that it is a valid and reliable scale.

Cite this article as: Başak N, Özgürsoy Uran BN, Sarıtaş Yüksel E. Treatment adherence of anti-TNF drugs in the patients with inflammatory bowel disease: A scale development study. Turk J Gastroenterol. 2022;33(4):336-345.

EISSN 2148-5607