Turkish Journal of Gastroenterology
Original Article

Monocyte/High-Density Lipoprotein Ratio Is an Indicator of Activity in Patients with Ulcerative Colitis

1.

Division of Gastroenterology, Department of Internal Medicine, Aksaray University Education and Research Hospital, Aksaray, Turkey

2.

Department of Gastroenterology, Mersin City Training and Research Hospital, Mersin, Turkey

3.

Department of Gastroenterology, Adana City Training and Research Hospital, Adana, Turkey

Turk J Gastroenterol 2022; 33: 329-335
DOI: 10.5152/tjg.2022.21401
Read: 310 Downloads: 40 Published: 11 April 2022

Background: In patients with ulcerative colitis, endoscopic and clinical indices are used to assess the disease activity. In addition, stud- ies have been carried out for easier and cheaper markers in recent years. For this purpose, we evaluated the monocyte/high-density lipoprotein ratio of the disease activity.

Methods: According to clinical activity and partial Mayo scores, a total of 114 patients, 53 in the active ulcerative colitis group and 61 in the ulcerative colitis remission group were included in the study. Monocyte/high-density lipoprotein ratio, neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, C-reactive protein, and erythrocyte sedimentation rate measurements of these 2 groups were recorded. Ulcerative colitis remission group and active ulcerative colitis group were compared in terms of activity.

Results: The monocyte/high-density lipoprotein ratio value in the active ulcerative colitis group was significantly higher than that of the ulcerative colitis remission group (10.68 ± 3.39, 6.68 ± 1.39, P < .001, respectively). The monocyte/high-density lipoprotein ratio value for active ulcerative colitis at a cut-off value of 7.4 had 83% sensitivity and 81% specificity. In the active ulcerative colitis group, neutrophil/lymphocyte ratio, C-reactive protein, and erythrocyte sedimentation rate values were significantly higher than the ulcerative colitis remission group (P < .001, P < .001, P < .001, respectively).

Conclusion: Monocyte/high-density lipoprotein ratio is an inexpensive and effective marker that can be used to determine the activity of ulcerative colitis.

Cite this article as: Yalçın MS, Yalaki S, Ölmez Ş, Taş A. Monocyte/high-density lipoprotein ratio is an indicator of activity in patients with ulcerative colitis. Turk J Gastroenterol. 2022;33(4):329-335.

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