Turkish Journal of Gastroenterology
Review

Medical treatment of gastroesophageal reflux disease

1.

Division of Gastroenterology, Ege University School of Medicine, İzmir, Turkey

2.

Clinic of Gastroenterology, Türkiye Yüksek İhtisas Training and Research Hospital, Ankara, Turkey

Turk J Gastroenterol 2017; 28: Supplement S48-S52
DOI: 10.5152/tjg.2017.13
Read: 139 Downloads: 40 Published: 25 July 2019

Abstract

Proton pump inhibitors (PPIs) are the most effective agents in the first-line and maintenance treatment of gastroesophageal reflux disease. As the grade of esophagitis increases, an increase is also observed in the level of endoscopic response to PPIs. In the first-line therapy of patients with severe esophagitis (Los Angeles (LA) Grade C-D), administration of a standard dose of PPIs bid has been reported to be more beneficial than PPIs qd. While any intermittant and low dose-continuous treatment can be chosen for the maintenance therapy of patients with non-erosive reflux disease or mild esophagitis (LA Grade A-B), continuous use of a standard dose of PPIs is preferred in the maintenance therapy of patients with severe esophagitis (LA Grade C-D). In patients who use PPIs for a long time, the drug must be stopped by gradually decreasing the dose.

 

 

 

Cite this article as: Bor S, Kalkan İH. Medical treatment of gastroesophageal reflux disease. Turk J Gastroenterol 2017;28(Suppl 1); S48-S52

 

 

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