Gastrointestinal Tract - Original Article

Extracellular matrix protein 1 gene rs3737240 single nucleotide polymorphism is associated with ulcerative colitis in Turkish patients

Volume 28 · Issue 4 Publish Date: July 15, 2017
Gupse Adalı Nagehan Ersoy Tunalı Elif Yorulmaz Necip Ozan Tiryakioğlu Sibel Güray Mungan Celal Ulaşoğlu Feruze Yılmaz Enç İlyas Tuncer
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Published In

Turkish Journal of Gastroenterology

Volume 28 · Issue 4

Pages: 254-259

History

Published Online: July 15, 2017

Copyright © 2017 Gupse Adalı, Nagehan Ersoy Tunalı, Elif Yorulmaz, Necip Ozan Tiryakioğlu, Sibel Güray Mungan, Celal Ulaşoğlu, Feruze Yılmaz Enç, İlyas Tuncer

Gupse Adalı
Department of Gastroenterology, İstanbul Medeniyet University School of Medicine, Göztepe Training and Research Hospital, İstanbul, Turkey
Nagehan Ersoy Tunalı
Department of Molecular Biology and Genetics, İstanbul Medeniyet University School of Medicine, Göztepe Training and Research Hospital, İstanbul, Turkey
Elif Yorulmaz
Departments of Gastroenterology and Internal Medicine, Göztepe Training and Research Hospital and Department of Pathology
Necip Ozan Tiryakioğlu
Department of Molecular Medicine, İstanbul University Institute of Experimental Research, İstanbul, Turkey
Sibel Güray Mungan
Department of Internal Medicine, İstanbul Medeniyet University School of Medicine, Göztepe Training and Research Hospital, İstanbul, Turkey
Celal Ulaşoğlu
Departments of Gastroenterology and Internal Medicine, İstanbul Göztepe Educational and Research Hospital, İstanbul
Feruze Yılmaz Enç
Department of Gastroenterology, İstanbul Medeniyet University School of Medicine, Göztepe Training and Research Hospital, İstanbul, Turkey
İlyas Tuncer
Departments of Gastroenterology and Internal Medicine, Göztepe Training and Research Hospital and Department of Pathology
Adalı, G., Ersoy Tunalı, N., Yorulmaz, E., Tiryakioğlu, N. O., Güray Mungan, S., Ulaşoğlu, C., … Tuncer, İlyas. (2017). Extracellular matrix protein 1 gene rs3737240 single nucleotide polymorphism is associated with ulcerative colitis in Turkish patients. Turkish Journal of Gastroenterology, 28(4), 254–259. https://doi.org/10.5152/tjg.2017.17043
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Abstract

Abstract Background/Aims: Ulcerative colitis (UC) and Crohn’s disease are chronic inflammatory diseases. Genetic, immunologic, and microbial factors play an important role in their pathogenesis. Extracellular matrix protein 1 (ECM1), a gene related to mucosal barrier function, has been shown to be associated with UC. This study aims to determine the relationship between ECM1 gene rs3737240 single nucleotide polymorphism (SNP) and UC in a group of Turkish patients. Materials and Methods: Ninety-four UC patients and 120 healthy controls were enrolled in the study. ECM1 gene rs3737240 SNP genotyping was performed using the polymerase chain reaction-restriction fragment length polymorphism method. Results: TT genotype was significantly more common in UC patients than in the healthy control group [p=0.034; odds ratio (OR) 2.34; 95% confidence interval (CI) 1.04-5.25]. The presence of C allele significantly lowered the UC risk (p=0.034; OR 0.42; 95% CI 0.19-0.95). TT genotype was significantly associated with azathioprine use in UC patients (p=0.037; OR 3.0; 95% CI 1.04-8.65). The C allele significantly reduced the probability of azathioprine use in UC patients (p=0.037; OR 0.33 CI 95% 0.11-0.96). No relation was found between rs3737240 SNP genotype and the phenotypical characteristics of UC patients. Conclusion: The TT genotype of ECM1 gene rs3737240 SNP significantly increased susceptibility for UC and azathioprine use in UC patients in a Turkish population. Cite this article as: Adalı G, Tunalı NE, Yorulmaz E, et al. Extracellular matrix protein 1 gene rs3737240 single nucleotide polymorphism is associated with ulcerative colitis in Turkish patients. Turk J Gastroenterol 2017; 28: 254-9.

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Article Info
Published In
Journal Turkish Journal of Gastroenterology
Volume / Issue Volume 28 · Issue 4
Pages 254-259
DOI 10.5152/tjg.2017.17043
History
Published Online July 15, 2017
Copyright
Copyright (c) 2017 Gupse Adalı, Nagehan Ersoy Tunalı, Elif Yorulmaz, Necip Ozan Tiryakioğlu, Sibel Güray Mungan, Celal Ulaşoğlu, Feruze Yılmaz Enç, İlyas Tuncer
Affiliations
Gupse Adalı
Department of Gastroenterology, İstanbul Medeniyet University School of Medicine, Göztepe Training and Research Hospital, İstanbul, Turkey
Nagehan Ersoy Tunalı
Department of Molecular Biology and Genetics, İstanbul Medeniyet University School of Medicine, Göztepe Training and Research Hospital, İstanbul, Turkey
Elif Yorulmaz
Departments of Gastroenterology and Internal Medicine, Göztepe Training and Research Hospital and Department of Pathology
Necip Ozan Tiryakioğlu
Department of Molecular Medicine, İstanbul University Institute of Experimental Research, İstanbul, Turkey
Sibel Güray Mungan
Department of Internal Medicine, İstanbul Medeniyet University School of Medicine, Göztepe Training and Research Hospital, İstanbul, Turkey
Celal Ulaşoğlu
Departments of Gastroenterology and Internal Medicine, İstanbul Göztepe Educational and Research Hospital, İstanbul
Feruze Yılmaz Enç
Department of Gastroenterology, İstanbul Medeniyet University School of Medicine, Göztepe Training and Research Hospital, İstanbul, Turkey
İlyas Tuncer
Departments of Gastroenterology and Internal Medicine, Göztepe Training and Research Hospital and Department of Pathology
Cite this Article
Adalı, G., Ersoy Tunalı, N., Yorulmaz, E., Tiryakioğlu, N. O., Güray Mungan, S., Ulaşoğlu, C., … Tuncer, İlyas. (2017). Extracellular matrix protein 1 gene rs3737240 single nucleotide polymorphism is associated with ulcerative colitis in Turkish patients. Turkish Journal of Gastroenterology, 28(4), 254–259. https://doi.org/10.5152/tjg.2017.17043
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