Published In
Turkish Journal of Gastroenterology
Volume 27 · Issue 2
Pages: 197-200
History
Published Online: March 15, 2016
Copyright © 2016 İlhami Gültepe, Metin Başaranoğlu, Mehmet Zorlu, Abdulhalim Şenyiğit, Emine Zeynep Taşkale, Sibel Zaralı, Kadri Atay, Emine Köroğlu
İlhami Gültepe
Department of Internal Medicine, Bezmialem Vakıf University Hospital, İstanbul, Turkey
Metin Başaranoğlu
Department of Internal Medicine, Division of Gastroenterology and Hepatology, Bezmialem Vakıf University School of Medicine, İstanbul, Turkey
Mehmet Zorlu
Department of Internal Medicine, Bezmialem Vakıf University Hospital, İstanbul, Turkey
Abdulhalim Şenyiğit
Department of Internal Medicine, Medicine Hospital, İstanbul, Turkey
Emine Zeynep Taşkale
Medical student, Bezmialem Vakıf University Faculty of Medicine, İstanbul, Turkey
Sibel Zaralı
Medical Student, Bezmialem Vakıf University School of Medicine, İstanbul, Turkey
Kadri Atay
Department of Gastroenterology, İstanbul University Cerrahpaşa School of Medicine, İstanbul, Turkey
Emine Köroğlu
Department of Gastroenterology, Kartal Dr. Lütfi Kırdar Training and Research Hospital, İstanbul, Turkey
Gültepe, İlhami, Başaranoğlu, M., Zorlu, M., Şenyiğit, A., Taşkale, E. Z., Zaralı, S., … Köroğlu, E. (2016). Low lipase levels as an independent marker of pancreatic cancer: a frequently neglected condition in clinical setting. Turkish Journal of Gastroenterology, 27(2), 197–200. https://doi.org/10.5152/tjg.2016.16056
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Abstract
Abstract Background/Aims: Low lipase levels, which may be an indication of low production due to organ failure, are frequently encountered in a clinical setting, but are usually overlooked. This study examined the values of low serum lipase levels and other clinical parameters in the diagnosis of several clinical conditions, such as in pancreatic cancer. Materials and Methods: Patients with low lipase levels (≤8 U/L) were included in this retrospective study. Clinical data, including diagnostic category, demographic properties, and biochemical and hematological measurements, including serum lipase levels, were extracted. A multivariate analysis was used to identify the independent predictors of certain diagnostic categories. Results: A total of 198 patients with low lipase levels were included. Among these patients with low lipase levels, 45 (22.7%) were diagnosed with pancreas cancer. Multivariate analysis identified low lipase level as a significant predictor of pancreas cancer (OR 0.70 [%95 CI, 0.52–0.93], p=0.02). For predicting pancreatic cancer, an optimal cut-off value of ≤5.5 U/L for lipase was utilized, which had a sensitivity and specificity of 76% and 37%, respectively. Conclusion: Low lipase levels close to zero may be an indication of pancreatic cancer and should not be underestimated in the clinical setting. However, large studies are warranted to delineate the exact diagnostic significance of such low lipase levels.
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Article Info
Published In
Journal
Turkish Journal of Gastroenterology
Volume / Issue
Volume 27 · Issue 2
Pages
197-200
History
Published Online
March 15, 2016
Copyright
Copyright (c) 2016 İlhami Gültepe, Metin Başaranoğlu, Mehmet Zorlu, Abdulhalim Şenyiğit, Emine Zeynep Taşkale, Sibel Zaralı, Kadri Atay, Emine Köroğlu
Affiliations
İlhami Gültepe
Department of Internal Medicine, Bezmialem Vakıf University Hospital, İstanbul, Turkey
Metin Başaranoğlu
Department of Internal Medicine, Division of Gastroenterology and Hepatology, Bezmialem Vakıf University School of Medicine, İstanbul, Turkey
Mehmet Zorlu
Department of Internal Medicine, Bezmialem Vakıf University Hospital, İstanbul, Turkey
Abdulhalim Şenyiğit
Department of Internal Medicine, Medicine Hospital, İstanbul, Turkey
Emine Zeynep Taşkale
Medical student, Bezmialem Vakıf University Faculty of Medicine, İstanbul, Turkey
Sibel Zaralı
Medical Student, Bezmialem Vakıf University School of Medicine, İstanbul, Turkey
Kadri Atay
Department of Gastroenterology, İstanbul University Cerrahpaşa School of Medicine, İstanbul, Turkey
Emine Köroğlu
Department of Gastroenterology, Kartal Dr. Lütfi Kırdar Training and Research Hospital, İstanbul, Turkey
Cite this Article
Gültepe, İlhami, Başaranoğlu, M., Zorlu, M., Şenyiğit, A., Taşkale, E. Z., Zaralı, S., … Köroğlu, E. (2016). Low lipase levels as an independent marker of pancreatic cancer: a frequently neglected condition in clinical setting. Turkish Journal of Gastroenterology, 27(2), 197–200. https://doi.org/10.5152/tjg.2016.16056
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