Published In
Turkish Journal of Gastroenterology
Volume 27 · Issue 1
Pages: 37-41
History
Published Online: January 15, 2016
Copyright © 2016 Mehmet Ağın, Gökhan Tümgör, Murat Alkan, Önder Özden, Mehmet Satar, Recep Tuncer
Mehmet Ağın
Department of Pediatric Gastroenterology, Çukurova University Medical Faculty, Adana, Turkey
Gökhan Tümgör
Departments of Pediatric Gastroenterology and Hepatology, Ege University School of Medicine, İzmir
Murat Alkan
Department of Pediatric Surgery, Çukurova University Medical Faculty, Adana, Turkey
Önder Özden
Department of Pediatric Surgery, Çukurova University Medical Faculty, Adana, Turkey
Mehmet Satar
Department of Neonatalogy, Çukurova University Medical Faculty, Adana, Turkey
Recep Tuncer
Department of Pediatric Surgery, Çukurova University Medical Faculty, Adana, Turkey
Ağın, M., Tümgör, G., Alkan, M., Özden, Önder, Satar, M., & Tuncer, R. (2016). Clues to the diagnosis of biliary atresia in neonatal cholestasis. Turkish Journal of Gastroenterology, 27(1), 37–41. https://doi.org/10.5152/tjg.2015.150379
Full Text
Full Text PDF
Full Text PDF
Abstract
Abstract Background/Aims: The purpose of this study was to identify important clues in differentiating biliary atresia (BA) from causes of neonatal cholestasis other than BA (non-BA) and establishing the reliability of current tests. Materials and Methods: Thirty-four patients with BA and 27 patients with non-BA cholestasis being monitored at the Çukurova University Medical Faculty, the Pediatric Gastroenterology Department and the Pediatric Surgery Department between 2009 and 2015 were retrospectively assessed. Results: Cases of early onset jaundice, acholic stool, gamma-glutamyl transferase (GGT) elevation, and absent or small gallbladder on ultrasonography (USG) were greater in the BA group, while the levels of consanguinity and splenomegaly were higher in the non-BA group. The highest positive predictive value and specificity was determined for a GGT level greater than 197 in addition to absent or small gallbladder on USG and acholic stool in the BA group. Moreover, the presence of acholic stool (97%) exhibited the highest sensitivity and accuracy in the diagnosis of BA. Conclusion: Pale stool, GGT elevation, and absent or small gallbladder on USG are the most reliable tests for diagnosing BA. We recommend that intraoperative cholangiography should be performed without waiting for further test results when a neonate or infant presents with acholic stool, high GGT values, and absent or small gallbladder on abdominal USG.
Most read articles by the same author(s)
- Nafiye Urgancı, Funda Ozgenc, Zarife Kuloğlu, Hasan Yüksekkaya, Sinan Sarı, Tülay Erkan, Zerrin Önal, Gönül Çaltepe, Mustafa Akçam, Duran Arslan, Nur Arslan, Reha Artan, Ayşen Aydoğan, Necati Balamtekin, Maşallah Baran, Gökhan Baysoy, Murat Çakır, Buket Dalgıç, Yaşar Doğan, Özlem Durmaz, Çiğdem Ecevıt, Makbule Eren, Selim Gökçe, Fulya Gülerman, Figen Gürakan, Samil Hızlı, Ishak Işık, Ayhan Gazi Kalaycı, Aydan Kansu, Tufan Kutlu, Hamza Karabiber, Erhun Kasırga, Günsel Kutluk, Ferdağ Özbay Hoşnut, Hasan Özen, Tanju Özkan, Yeşim Öztürk, Özlem Bekem Soylu, Engin Tutar, Gökhan Tümgör, Fatih Ünal, Meltem Ugraş, Gonca Üstündağ, Aytaç Yaman, Turkish IBD Study Group, Familial Mediterranean Fever Mutation Analysis in Pediatric Patients With İnflammatory Bowel Disease: A Multicenter Study , Turkish Journal of Gastroenterology: Vol. 32 No. 3 (2021): Turkish Journal of Gastroenterology
- Yusuf Kayar, Ramazan Dertli, Şevki Konür, Mehmet Ağın, Abdullah Al Kafee, Bülent Baran, Aslı Çiftçibaşı Örmeci, Filiz Akyüz, Kadir Demir, Fatih Beşışık, Sabahattin Kaymakoğlu, Mucocutaneous Manifestations and Associated Factors in Patients with Crohn’s Disease , Turkish Journal of Gastroenterology: Vol. 33 No. 11 (2022): Turkish Journal of Gastroenterology
- Sibel Yavuz, Ferhat Can Pişkin, Cemil Oktay, Süreyya Soyupak, Gökhan Tümgör, Evaluation of the Liver and Pancreas by 2D Shear Wave Elastography in Pediatric Wilson’s Disease , Turkish Journal of Gastroenterology: Vol. 33 No. 2 (2022): Turkish Journal of Gastroenterology
- Gökhan Tümgör, Masallah Baran, Murat Çakır, Hasan Ali Yüksekkaya, Sema Aydoğdu, Comparison of standard and standard plus vitamin E therapy for Helicobacter pylori eradications in children , Turkish Journal of Gastroenterology: Vol. 25 No. 1 (2014): Turkish Journal of Gastroenterology
- Sema Aydoğdu, Gökhan TÜMGÖR, Deniz Yılmaz KARAPINAR, Bülent KARAPINAR, Çiğdem ARIKAN, Murat KILIÇ, Yeşim AYDINOK, Severe aplastic anemia following liver transplantation in a patient with non-A-E fulminant hepatitis , Turkish Journal of Gastroenterology: Vol. 22 No. 3 (2011): Turkish Journal of Gastroenterology
- Gökhan Tümgör, Recep Tuncer, Dinçer Yıldızdaş, Abdullah Ülkü, Atılgan Tolga Akcam, Haluk Demiryürek, A case of uneventful ABO-incompatible liver transplantation from a deceased donor managed with routine immunosuppressive treatment , Turkish Journal of Gastroenterology: Vol. 25 No. 6 (2014): Turkish Journal of Gastroenterology
- Emre Alhan, Banu Kozanoğlu, Gökhan Tümgör, Ümit Çelik, Akgün Yaman, Nafiz Bozdemir, Epidemiological shift of hepatitis A in central Adana, Turkey , Turkish Journal of Gastroenterology: Vol. 25 No. 1 (2014): Turkish Journal of Gastroenterology
Article Info
Published In
Journal
Turkish Journal of Gastroenterology
Volume / Issue
Volume 27 · Issue 1
Pages
37-41
History
Published Online
January 15, 2016
Copyright
Copyright (c) 2016 Mehmet Ağın, Gökhan Tümgör, Murat Alkan, Önder Özden, Mehmet Satar, Recep Tuncer
Affiliations
Mehmet Ağın
Department of Pediatric Gastroenterology, Çukurova University Medical Faculty, Adana, Turkey
Gökhan Tümgör
Departments of Pediatric Gastroenterology and Hepatology, Ege University School of Medicine, İzmir
Murat Alkan
Department of Pediatric Surgery, Çukurova University Medical Faculty, Adana, Turkey
Önder Özden
Department of Pediatric Surgery, Çukurova University Medical Faculty, Adana, Turkey
Mehmet Satar
Department of Neonatalogy, Çukurova University Medical Faculty, Adana, Turkey
Recep Tuncer
Department of Pediatric Surgery, Çukurova University Medical Faculty, Adana, Turkey
Cite this Article
Ağın, M., Tümgör, G., Alkan, M., Özden, Önder, Satar, M., & Tuncer, R. (2016). Clues to the diagnosis of biliary atresia in neonatal cholestasis. Turkish Journal of Gastroenterology, 27(1), 37–41. https://doi.org/10.5152/tjg.2015.150379
Outlines