Original Article

Mucocutaneous Manifestations and Associated Factors in Patients with Crohn’s Disease

Volume 33 · Issue 11 Publish Date: November 15, 2022
Yusuf Kayar Ramazan Dertli Şevki Konür Mehmet Ağın Abdullah Al Kafee Bülent Baran Aslı Çiftçibaşı Örmeci Filiz Akyüz Kadir Demir Fatih Beşışık Sabahattin Kaymakoğlu
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Turkish Journal of Gastroenterology

Volume 33 · Issue 11

Pages: 945-954

History

Published Online: November 15, 2022

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright © 2022 Yusuf Kayar, Ramazan Dertli, Şevki Konür, Mehmet Ağın, Abdullah Al Kafee, Bülent Baran, Aslı Çiftçibaşı Örmeci, Filiz Akyüz, Kadir Demir, Fatih Beşışık, Sabahattin Kaymakoğlu

Yusuf Kayar
Department of Internal Medicine, Division of Gastroenterology, Bezmialem Vakıf University School of Medicine, İstanbul, Turkey
Ramazan Dertli
Department of Internal Medicine, Division of Gastroenterology, Necmettin Erbakan University Meram School of Medicine, Konya, Turkey
Şevki Konür
Department of Internal Medicine, Van Teaching and Research Hospital, Health Sciences University, Van, Turkey
Mehmet Ağın
Department of Pediatric Gastroenterology, Çukurova University Medical Faculty, Adana, Turkey
Abdullah Al Kafee
Department of Biomedical Engineering, Fatih University Institute of Biomedical Engineering, İstanbul, Turkey
Bülent Baran
Department of Gastroenterology, Van Region Training and Research Hospital, Van, Turkey
Aslı Çiftçibaşı Örmeci
Division of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Filiz Akyüz
Covering the Cover Editor
Kadir Demir
İstanbul Üniversitesi, İstanbul Tıp Fakültesi Gastroenteropatoloji Bilim Dalı ve Patoloji anabilim Dalı, İstanbul
Fatih Beşışık
Departments of Gastroenterohepatology, İstanbul University İstanbul Medical Faculty, İstanbul
Sabahattin Kaymakoğlu
Department of Gastroenterology, İstanbul University, İstanbul School of Medicine, İstanbul
Kayar, Y., Dertli, R., Konür, Şevki, Ağın, M., Al Kafee, A., Baran, B., … Kaymakoğlu, S. (2022). Mucocutaneous Manifestations and Associated Factors in Patients with Crohn’s Disease. Turkish Journal of Gastroenterology, 33(11), 945–954. https://doi.org/10.5152/tjg.2022.21750
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Abstract

Background: One-third of all extraintestinal manifestations are mucocutaneous findings in patients with Crohn’s disease and there is a relationship between some risk factors. Our aim is to evaluate factors associated with mucocutaneous manifestations in our cohort of patients with Crohn’s disease with a follow-up duration of up to 25 years. Methods: In the study, 336 patients with Crohn’s disease who were followed up between March 1986 and October 2011 were included. The demographic characteristics, Crohn’s disease-related data, and accompanying mucocutaneous manifestations were recorded. The cumulative probability of mucocutaneous extraintestinal manifestations and possible risk factors were analyzed. Results: Oral and skin involvement were detected in 109 (32%) and 31 (9.2%) patients, respectively. The cumulative probability of developing oral and skin manifestations were 43.2% and 20.3%, respectively. Cox regression analysis showed that female gender (odds ratio: 3.28, 95% CI: 1.51-7.14, P = .003) and corticosteroid use (odds ratio: 7.88, 95% CI: 1.07-57.97, P = .043) are independently associated with the development of skin manifestations, while family history (odds ratio: 3.59, 95% CI: 2.18-5.93, P < .001) and inflammatory-type disease (odds ratio: 1.776, 95% CI: 1.21-2.61, P = .004) were independently associated with the development of oral ulcers. Conclusion: Mucocutaneous extraintestinal manifestations are associated with female gender, corticosteroid use, family history, and disease type in a large cohort of patients with Crohn’s disease. Defining the specific relationships of immune-mediated diseases will help to better understand the pathogenesis of Crohn’s disease and associated mucocutaneous manifestations and to use more effective treatments. Cite this article as: Kayar Y, Dertli R, Konür S, et al. Mucocutaneous manifestations and associated factors in patients with Crohn’s disease. Turk J Gastroenterol. 2022;33(11):945-954.

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Article Info
Published In
Journal Turkish Journal of Gastroenterology
Volume / Issue Volume 33 · Issue 11
Pages 945-954
DOI 10.5152/tjg.2022.21750
History
Published Online November 15, 2022
License
Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Copyright
Copyright (c) 2022 Yusuf Kayar, Ramazan Dertli, Şevki Konür, Mehmet Ağın, Abdullah Al Kafee, Bülent Baran, Aslı Çiftçibaşı Örmeci, Filiz Akyüz, Kadir Demir, Fatih Beşışık, Sabahattin Kaymakoğlu
Affiliations
Yusuf Kayar
Department of Internal Medicine, Division of Gastroenterology, Bezmialem Vakıf University School of Medicine, İstanbul, Turkey
Ramazan Dertli
Department of Internal Medicine, Division of Gastroenterology, Necmettin Erbakan University Meram School of Medicine, Konya, Turkey
Şevki Konür
Department of Internal Medicine, Van Teaching and Research Hospital, Health Sciences University, Van, Turkey
Mehmet Ağın
Department of Pediatric Gastroenterology, Çukurova University Medical Faculty, Adana, Turkey
Abdullah Al Kafee
Department of Biomedical Engineering, Fatih University Institute of Biomedical Engineering, İstanbul, Turkey
Bülent Baran
Department of Gastroenterology, Van Region Training and Research Hospital, Van, Turkey
Aslı Çiftçibaşı Örmeci
Division of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Filiz Akyüz
Covering the Cover Editor
Kadir Demir
İstanbul Üniversitesi, İstanbul Tıp Fakültesi Gastroenteropatoloji Bilim Dalı ve Patoloji anabilim Dalı, İstanbul
Fatih Beşışık
Departments of Gastroenterohepatology, İstanbul University İstanbul Medical Faculty, İstanbul
Sabahattin Kaymakoğlu
Department of Gastroenterology, İstanbul University, İstanbul School of Medicine, İstanbul
Cite this Article
Kayar, Y., Dertli, R., Konür, Şevki, Ağın, M., Al Kafee, A., Baran, B., … Kaymakoğlu, S. (2022). Mucocutaneous Manifestations and Associated Factors in Patients with Crohn’s Disease. Turkish Journal of Gastroenterology, 33(11), 945–954. https://doi.org/10.5152/tjg.2022.21750
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