Original Article

Influence of vitamin C and E supplementation on the eradication rates of triple and quadruple eradication regimens for Helicobacter pylori infection

Volume 26 · Issue 6 Publish Date: November 15, 2015
Hakan Demirci Sevil Uygun İlikhan Kadir Öztürk Yücel Üstündağ Ömer Kurt Muammer Bilici Furuzan Köktürk Ahmet Uygun
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Turkish Journal of Gastroenterology

Volume 26 · Issue 6

Pages: 456-460

History

Published Online: November 15, 2015

Copyright © 2015 Hakan Demirci, Sevil Uygun İlikhan, Kadir Öztürk, Yücel Üstündağ, Ömer Kurt, Muammer Bilici, Furuzan Köktürk, Ahmet Uygun

Hakan Demirci
Department of Gastroenterology, Gülhane Military Medical Academy, Ankara, Turkey
Sevil Uygun İlikhan
Department of Internal Medicine, Bülent Ecevit University Faculty of Medicine, Zonguldak, Turkey
Kadir Öztürk
Department of Gastroenterology, Gülhane Military Medical Academy, Ankara, Turkey
Yücel Üstündağ
Hacettepe University Medical School Departments of Internal Medicine Ankara, Turkey
Ömer Kurt
Department of Gastroenterology, Gülhane Military Medical Academy, Ankara, Turke
Muammer Bilici
Department of Internal Medicine, Bülent Ecevit University Faculty of Medicine, Zonguldak, Turkey
Furuzan Köktürk
Department of Statistics, Bülent Ecevit University Faculty of Medicine, Zonguldak, Turkey
Ahmet Uygun
Departments of Gastroenterology, Gülhane Military Medical Academy, Ankara
Demirci, H., Uygun İlikhan, S., Öztürk, K., Üstündağ, Y., Kurt, Ömer, Bilici, M., … Uygun, A. (2015). Influence of vitamin C and E supplementation on the eradication rates of triple and quadruple eradication regimens for Helicobacter pylori infection. Turkish Journal of Gastroenterology, 26(6), 456–460. https://doi.org/10.5152/tjg.2015.0233
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Abstract

Abstract Background/Aims: In our study, we aimed to assess the effect of vitamin E and C supplementation to triple and quadruple Helicobacter pylori eradication regimens. Materials and Methods: Four hundred patients with H. pylori infection were classified into four groups. Patients in group A (n=100) received amoxicillin, clarithromycin, and lansoprazole for 2 weeks. In group B, patients (n=100) received vitamins C and E for a month, in addition to amoxicillin, clarithromycin, and lansoprazole for 2 weeks. Patients in group C (n=100) received amoxicillin, clarithromycin, lansoprazole, and bismuth subcitrate for 2 weeks, whereas those in group D (n=100) received vitamins C and E for a month, in addition to amoxicillin, clarithromycin, lansoprazole, and bismuth subcitrate for 2 weeks. H. pylori eradication was assessed with the C14 urea breath test 2 months after the end of the therapy. The eradication rate was assessed using per-protocol (PP) and intention-to-treat (ITT) analyses. Results: Three hundred forty-eight patients finished the study. The eradication of H. pylori was achieved in 63 of 84 patients (75%) by PP and 63 of 100 (63%) by ITT analysis in group A, 60 of 84 (71.4%) by PP and 60 of 100 (60%) by ITT analysis in group B, 72 of 89 (80.9 %) by PP and 72 of 100 (72%) by ITT analysis in group C, and 76 of 91 (83.5%) by PP and 76 of 100 (76%) by ITT analysis in group D. There was no remarkable change between groups A and B (p>0.05). Similar results were also found between groups D and C (p>0.05). Conclusion: This study revealed that supplementing vitamins C and E to either the triple or quadruple therapies did not provide an additional advantage for achieving significantly higher eradication rates for H. pylori.

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Article Info
Published In
Journal Turkish Journal of Gastroenterology
Volume / Issue Volume 26 · Issue 6
Pages 456-460
DOI 10.5152/tjg.2015.0233
History
Published Online November 15, 2015
Copyright
Copyright (c) 2015 Hakan Demirci, Sevil Uygun İlikhan, Kadir Öztürk, Yücel Üstündağ, Ömer Kurt, Muammer Bilici, Furuzan Köktürk, Ahmet Uygun
Affiliations
Hakan Demirci
Department of Gastroenterology, Gülhane Military Medical Academy, Ankara, Turkey
Sevil Uygun İlikhan
Department of Internal Medicine, Bülent Ecevit University Faculty of Medicine, Zonguldak, Turkey
Kadir Öztürk
Department of Gastroenterology, Gülhane Military Medical Academy, Ankara, Turkey
Yücel Üstündağ
Hacettepe University Medical School Departments of Internal Medicine Ankara, Turkey
Ömer Kurt
Department of Gastroenterology, Gülhane Military Medical Academy, Ankara, Turke
Muammer Bilici
Department of Internal Medicine, Bülent Ecevit University Faculty of Medicine, Zonguldak, Turkey
Furuzan Köktürk
Department of Statistics, Bülent Ecevit University Faculty of Medicine, Zonguldak, Turkey
Ahmet Uygun
Departments of Gastroenterology, Gülhane Military Medical Academy, Ankara
Cite this Article
Demirci, H., Uygun İlikhan, S., Öztürk, K., Üstündağ, Y., Kurt, Ömer, Bilici, M., … Uygun, A. (2015). Influence of vitamin C and E supplementation on the eradication rates of triple and quadruple eradication regimens for Helicobacter pylori infection. Turkish Journal of Gastroenterology, 26(6), 456–460. https://doi.org/10.5152/tjg.2015.0233
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