Original Article

Efficacy of autologous mesenchymal stem cell transplantation in patients with liver cirrhosis

Volume 26 · Issue 3 Publish Date: May 15, 2015
Murat Kantarcıoğlu Hakan Demirci Ferit Avcu Yıldırım Karslıoğlu Mustafa Alpaslan Babayiğit Bülent Karaman Kadir Öztürk Hasan Gürel Meral Akdoğan Kayhan Sabite Kaçar Ayhan Kubar Gürol Öksüzoğlu Ali Uğur Ural Sait Bağcı
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Published In

Turkish Journal of Gastroenterology

Volume 26 · Issue 3

Pages: 244-250

History

Published Online: May 15, 2015

Copyright © 2015 Murat Kantarcıoğlu, Hakan Demirci, Ferit Avcu, Yıldırım Karslıoğlu, Mustafa Alpaslan Babayiğit, Bülent Karaman, Kadir Öztürk, Hasan Gürel, Meral Akdoğan Kayhan, Sabite Kaçar, Ayhan Kubar, Gürol Öksüzoğlu, Ali Uğur Ural, Sait Bağcı

Murat Kantarcıoğlu
Departments of Gastroenterology, Gülhane Military Medical Academy, Ankara
Hakan Demirci
Department of Gastroenterology, Gülhane Military Medical Academy, Ankara, Turkey
Ferit Avcu
Department of Hematology, Gülhane Military Medical Academy, Ankara, Turkey
Yıldırım Karslıoğlu
Department of Pathology, Gülhane Military Medical Academy, School of Medicine, Ankara
Mustafa Alpaslan Babayiğit
Department of Public Health, Gülhane Military Medical Academy, Ankara, Turkey
Bülent Karaman
Department of Radiology, Gülhane Military Medical Academy, Ankara, Turkey
Kadir Öztürk
Department of Gastroenterology, Gülhane Military Medical Academy, Ankara, Turkey
Hasan Gürel
Department of Gastroenterology, Gülhane Military Medical Academy, Ankara, Turkey
Meral Akdoğan Kayhan
Department of Gastroenterology, Türkiye Yüksek Ihtisas Hospital, Ankara, Turkey
Sabite Kaçar
Department of Gastroenterology, Ankara Yüksek İhtisas Research and Training Hospital, Ankara, Turkey
Ayhan Kubar
Department of Microbiology, Gülhane Military Medical Academy, Ankara, Turkey
Gürol Öksüzoğlu
Hacettepe Üniversitesi Tıp Fakültesi, İç Hastalıkları, Gastroenteroloji Bilim Dalı ve Başkent Üniversitesi Tıp Fakültesi, Gastroenteroloji1 Bilim Dalı, Ankara
Ali Uğur Ural
Department of Hematology, Bayındır Hospital, Ankara, Turkey
Sait Bağcı
Department of Gastroenterology, Gülhane Military Medical Academy, Ankara, Turkey
Kantarcıoğlu, M., Demirci, H., Avcu, F., Karslıoğlu, Y., Babayiğit, M. A., Karaman, B., … Bağcı, S. (2015). Efficacy of autologous mesenchymal stem cell transplantation in patients with liver cirrhosis. Turkish Journal of Gastroenterology, 26(3), 244–250. https://doi.org/10.5152/tjg.2015.0074
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Abstract

Abstract Background/Aims: Because of several limitations and complications of liver transplantation, new alternative treatment modalities are required for patients with liver cirrhosis. Many study results encourage the use of autologous bone marrow-derived mesenchymal stem cells for liver diseases. In this study, we assessed the impact of autologous mesenchymal stem cell transplantation on liver tissue and liver chemistry. Materials and Methods: Twenty-five patients with biopsy-proven liver cirrhosis were enrolled in the study. Patients received 1×106 autologous mesenchymal stem cells/kg via a peripheral vein. Biochemical parameters were checked monthly. Periodical radiological screening and liver biopsies before mesenchymal stem cell transplantation were performed after 6 months. Liver specimens were assessed by a pathologist. Results: No side effect was observed and the mesenchymal stem cell transplantation procedure was well tolerated. Twelve patients completed the study. In 8 patients, improvements in Model for End-Stage Liver Disease (MELD) scores were observed. Serum albumin levels markedly increased in the third month. In patients with non-responder hepatitis C, HCV RNA levels both became negative after mesenchymal stem cell transplantation. Histopathological examinations of liver tissues before and at 6 months after transplantation revealed no change in liver tissue regeneration or fibrosis. However, in 5 patients, hepatitis activity index scores decreased. Conclusion: Autologous mesenchymal stem cell transplantation via peripheral vein is safe and feasible. Consecutive liver biopsy examinations suggested that mesenchymal stem cells could not reach the liver in a sufficient amount. Improvement in patients and clearance of HCV RNA may have occurred through immunomodulatory mediators secreted by transplanted mesenchymal stem cells, namely the “endocrine” effect.

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Article Info
Published In
Journal Turkish Journal of Gastroenterology
Volume / Issue Volume 26 · Issue 3
Pages 244-250
DOI 10.5152/tjg.2015.0074
History
Published Online May 15, 2015
Copyright
Copyright (c) 2015 Murat Kantarcıoğlu, Hakan Demirci, Ferit Avcu, Yıldırım Karslıoğlu, Mustafa Alpaslan Babayiğit, Bülent Karaman, Kadir Öztürk, Hasan Gürel, Meral Akdoğan Kayhan, Sabite Kaçar, Ayhan Kubar, Gürol Öksüzoğlu, Ali Uğur Ural, Sait Bağcı
Affiliations
Murat Kantarcıoğlu
Departments of Gastroenterology, Gülhane Military Medical Academy, Ankara
Hakan Demirci
Department of Gastroenterology, Gülhane Military Medical Academy, Ankara, Turkey
Ferit Avcu
Department of Hematology, Gülhane Military Medical Academy, Ankara, Turkey
Yıldırım Karslıoğlu
Department of Pathology, Gülhane Military Medical Academy, School of Medicine, Ankara
Mustafa Alpaslan Babayiğit
Department of Public Health, Gülhane Military Medical Academy, Ankara, Turkey
Bülent Karaman
Department of Radiology, Gülhane Military Medical Academy, Ankara, Turkey
Kadir Öztürk
Department of Gastroenterology, Gülhane Military Medical Academy, Ankara, Turkey
Hasan Gürel
Department of Gastroenterology, Gülhane Military Medical Academy, Ankara, Turkey
Meral Akdoğan Kayhan
Department of Gastroenterology, Türkiye Yüksek Ihtisas Hospital, Ankara, Turkey
Sabite Kaçar
Department of Gastroenterology, Ankara Yüksek İhtisas Research and Training Hospital, Ankara, Turkey
Ayhan Kubar
Department of Microbiology, Gülhane Military Medical Academy, Ankara, Turkey
Gürol Öksüzoğlu
Hacettepe Üniversitesi Tıp Fakültesi, İç Hastalıkları, Gastroenteroloji Bilim Dalı ve Başkent Üniversitesi Tıp Fakültesi, Gastroenteroloji1 Bilim Dalı, Ankara
Ali Uğur Ural
Department of Hematology, Bayındır Hospital, Ankara, Turkey
Sait Bağcı
Department of Gastroenterology, Gülhane Military Medical Academy, Ankara, Turkey
Cite this Article
Kantarcıoğlu, M., Demirci, H., Avcu, F., Karslıoğlu, Y., Babayiğit, M. A., Karaman, B., … Bağcı, S. (2015). Efficacy of autologous mesenchymal stem cell transplantation in patients with liver cirrhosis. Turkish Journal of Gastroenterology, 26(3), 244–250. https://doi.org/10.5152/tjg.2015.0074
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