Original Article

Clinical course and predictors of total colectomy in ulcerative colitis; a referral center experience from Turkey

Volume 26 · Issue 1 Publish Date: January 15, 2015
İsmail Hakkı Kalkan Ülkü Dağlı Murat Kekilli Erkin Öztaş Bilge Tunç Aysel Ülker
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Published In

Turkish Journal of Gastroenterology

Volume 26 · Issue 1

Pages: 25-30

History

Published Online: January 15, 2015

Copyright © 2015 İsmail Hakkı Kalkan, Ülkü Dağlı, Murat Kekilli, Erkin Öztaş, Bilge Tunç, Aysel Ülker

İsmail Hakkı Kalkan
Department of Gastroenterology, Türkiye Yüksek ihtisas Training and Research Hospital, Ankara
Ülkü Dağlı
Türkiye yüksek İhtisas Hastanesi Gastroenteroloji Kliniği, Ankara
Murat Kekilli
Department of Gastroenterology, Ankara Training and Research Hospital, Ankara, Turkey
Erkin Öztaş
Department of Gastroenterology, Ankara Yüksek İhtisas Research and Training Hospital, Ankara, Turkey
Bilge Tunç
Türkiye Yüksek İhtisas Hastanesi, Gastroenteroloji Kliniği, Ankara
Aysel Ülker
Departments of Gastroenterology and Hematology, Türkiye Yüksek İhtisas Hospital, Ankara
Kalkan, İsmail H., Dağlı, Ülkü, Kekilli, M., Öztaş, E., Tunç, B., & Ülker, A. (2015). Clinical course and predictors of total colectomy in ulcerative colitis; a referral center experience from Turkey. Turkish Journal of Gastroenterology, 26(1), 25–30. https://doi.org/10.5152/tjg.2015.5071
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Abstract

Abstract Background/Aims: We aimed to describe the clinical course of Ulcerative colitis (UC) and the factors that predict the need for total colectomy in Turkish patients with severe UC receiving regular follow up. Materials and Methods: We analyzed the demographic and clinical characteristics of 612 patients with UC receiving regular follow up between 1994 and 2010 in a tertiary referral center in Ankara. Results: Men accounted for 58% of patients (M:F ratio, 1.4:1), and the mean age at diagnosis was 37.9 years. Of these, 32% had distal colitis and 8.8% had further extension, and 39 patients (6.4%) had chronic active disease. Steroid dependency and steroid resistance rates were 7.5% and 17.2%, respectively. In multivariate analysis, steroid dependency (p=0.04), steroid resistance (p=0.002), further extension (p<0.001), presence of extensive disease (p=0.006), and chronic active disease (p<0.001) were independent predictors of the need for total colectomy. Patients with chronic active disease had lower total colectomy free survival (p<0.001). Conclusion: The predictors of total colectomy were comparable with those previously reported in the literature. However, we identified further extension in disease localization to predict the need for total colectomy.

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Article Info
Published In
Journal Turkish Journal of Gastroenterology
Volume / Issue Volume 26 · Issue 1
Pages 25-30
DOI 10.5152/tjg.2015.5071
History
Published Online January 15, 2015
Copyright
Copyright (c) 2015 İsmail Hakkı Kalkan, Ülkü Dağlı, Murat Kekilli, Erkin Öztaş, Bilge Tunç, Aysel Ülker
Affiliations
İsmail Hakkı Kalkan
Department of Gastroenterology, Türkiye Yüksek ihtisas Training and Research Hospital, Ankara
Ülkü Dağlı
Türkiye yüksek İhtisas Hastanesi Gastroenteroloji Kliniği, Ankara
Murat Kekilli
Department of Gastroenterology, Ankara Training and Research Hospital, Ankara, Turkey
Erkin Öztaş
Department of Gastroenterology, Ankara Yüksek İhtisas Research and Training Hospital, Ankara, Turkey
Bilge Tunç
Türkiye Yüksek İhtisas Hastanesi, Gastroenteroloji Kliniği, Ankara
Aysel Ülker
Departments of Gastroenterology and Hematology, Türkiye Yüksek İhtisas Hospital, Ankara
Cite this Article
Kalkan, İsmail H., Dağlı, Ülkü, Kekilli, M., Öztaş, E., Tunç, B., & Ülker, A. (2015). Clinical course and predictors of total colectomy in ulcerative colitis; a referral center experience from Turkey. Turkish Journal of Gastroenterology, 26(1), 25–30. https://doi.org/10.5152/tjg.2015.5071
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