Original Article

Comparative assessment of prognostic value for revised-mayo risk model and child-pugh score in patients with primary sclerosing cholangitis

Volume 26 · Issue 1 Publish Date: January 15, 2015
Erkin Öztaş Diğdem Özer Etik Rahşan Olga Metin İsmail Hakkı Kalkan Erkan Parlak Fatih Oğuz Önder Mehmet Arhan Nurgül Şaşmaz
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Published In

Turkish Journal of Gastroenterology

Volume 26 · Issue 1

Pages: 31-35

History

Published Online: January 15, 2015

Copyright © 2015 Erkin Öztaş, Diğdem Özer Etik, Rahşan Olga Metin, İsmail Hakkı Kalkan, Erkan Parlak, Fatih Oğuz Önder, Mehmet Arhan, Nurgül Şaşmaz

Erkin Öztaş
Department of Gastroenterology, Ankara Yüksek İhtisas Research and Training Hospital, Ankara, Turkey
Diğdem Özer Etik
Department of Gastroenterology, Yüksek İhtisas Teaching and Research Hospital, Ankara
Rahşan Olga Metin
Department of Gastroenterology, Yüksek İhtisas Education and Research Hospital, Ankara, Turkey
İsmail Hakkı Kalkan
Department of Gastroenterology, Türkiye Yüksek ihtisas Training and Research Hospital, Ankara
Erkan Parlak
Department of Gastroenterology, Sakarya University School of Medicine, Sakarya, Turkey
Fatih Oğuz Önder
Departments of Internal Medicine, Ankara University, School of Medicine, Ankara
Mehmet Arhan
Department of Gastroenterology, Yüksek İhtisas Education and Research Hospital, Ankara
Nurgül Şaşmaz
Department of Gastroenterology, Türkiye Yüksek İhtisas Training and Research Hospital, Ankara, Turkey
Öztaş, E., Özer Etik, D., Metin, R. O., Kalkan, İsmail H., Parlak, E., Önder, F. O., … Şaşmaz, N. (2015). Comparative assessment of prognostic value for revised-mayo risk model and child-pugh score in patients with primary sclerosing cholangitis. Turkish Journal of Gastroenterology, 26(1), 31–35. https://doi.org/10.5152/tjg.2015.4479
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Abstract

Abstract Background/Aims: The aim of this study was to compare the utility of the revised Mayo risk model (rMRM) and Child-Pugh scores (CPSs) for predicting the prognosis of disease in patients with primary sclerosing cholangitis (PSC). Materials and Methods: Patients were divided into 2 groups: Group I (37 patients; alive and not requiring liver transplantation) and Group II (8 patients; deceased or requiring liver transplantation). rMRM suggests the possible survival percentage over a 4-year period. Thus, rMRM scores and CPSs on the first visit were calculated from the data at the time of diagnosis for patients diagnosed with PSC <4 years ago. rMRM scores and CPSs of patients with >4 years of follow-up were calculated using data from the visit 4 years prior to their last follow-up. Results: Bivariate analyses showed that need for liver transplantation/mortality was correlated with either first visit CPS (r=0.481, p=0.001) or rMRM (r=0.452, p=0.002). Analysis of the area under the curve showed that both models performed similarly in terms of predicting the need for liver transplantation/mortality (rMRM: 0.780; CPS: 0.762; p=0.8). There was a significant difference in Kaplan-Meier survival rates between Group I and Group II for both risk models (rMRM: p<0.001; CPS: p<0.001) when the decisive event was death or need for liver transplantation. Conclusion: Both rMRM and CPSs are useful in risk assessment of patients with PSC. The ability to predict prognosis is similar for both risk models.

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Article Info
Published In
Journal Turkish Journal of Gastroenterology
Volume / Issue Volume 26 · Issue 1
Pages 31-35
DOI 10.5152/tjg.2015.4479
History
Published Online January 15, 2015
Copyright
Copyright (c) 2015 Erkin Öztaş, Diğdem Özer Etik, Rahşan Olga Metin, İsmail Hakkı Kalkan, Erkan Parlak, Fatih Oğuz Önder, Mehmet Arhan, Nurgül Şaşmaz
Affiliations
Erkin Öztaş
Department of Gastroenterology, Ankara Yüksek İhtisas Research and Training Hospital, Ankara, Turkey
Diğdem Özer Etik
Department of Gastroenterology, Yüksek İhtisas Teaching and Research Hospital, Ankara
Rahşan Olga Metin
Department of Gastroenterology, Yüksek İhtisas Education and Research Hospital, Ankara, Turkey
İsmail Hakkı Kalkan
Department of Gastroenterology, Türkiye Yüksek ihtisas Training and Research Hospital, Ankara
Erkan Parlak
Department of Gastroenterology, Sakarya University School of Medicine, Sakarya, Turkey
Fatih Oğuz Önder
Departments of Internal Medicine, Ankara University, School of Medicine, Ankara
Mehmet Arhan
Department of Gastroenterology, Yüksek İhtisas Education and Research Hospital, Ankara
Nurgül Şaşmaz
Department of Gastroenterology, Türkiye Yüksek İhtisas Training and Research Hospital, Ankara, Turkey
Cite this Article
Öztaş, E., Özer Etik, D., Metin, R. O., Kalkan, İsmail H., Parlak, E., Önder, F. O., … Şaşmaz, N. (2015). Comparative assessment of prognostic value for revised-mayo risk model and child-pugh score in patients with primary sclerosing cholangitis. Turkish Journal of Gastroenterology, 26(1), 31–35. https://doi.org/10.5152/tjg.2015.4479
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