Turkish Journal of Gastroenterology
Case Report

Treatment with a combination of bosentan and sildenafil allows for successful liver transplantation in a patient with portopulmonary hypertension


Department of Cardiology, Uludağ University Faculty of Medicine, Bursa, Turkey

Turk J Gastroenterol 2014; 25: 429-432
DOI: 10.5152/tjg.2014.7688
Read: 52 Downloads: 7 Published: 25 July 2019


Pulmonary arterial hypertension (PAH) that occurs in the setting of cirrhosis and portal hypertension is referred to as portopulmonary hypertension (PPHTN). Liver transplantation (LTx) is curative, but the presence of moderate-tosevere PPHTN may be a contraindication for transplantation because of the elevated risk of peri- and post transplantation morbidity and mortality. We report a successful liver transplantation in a patient with liver cirrhosis after treatment of moderate-to-severe PPHTN with a combination of the dual endothelin receptor antagonist bosentan and the specific phosphodiesterase-5 inhibitor sildenafil.

EISSN 2148-5607