Turkish Journal of Gastroenterology
Original Article

Temporary placement of a paclitaxel or rapamycin-eluting stent is effective to reduce stenting induced inflammatory reaction and scaring in benign cardia stricture models

1.

Department of Radiology, The Tenth Affiliated People’s Hospital, Shanghai Tong Ji University Faculty of Medicine, Shanghai, China; Department of Radiology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital600 Yi Shan Road, Shanghai, China

2.

Department of Radiology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital600 Yi Shan Road, Shanghai, China.

3.

Department of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou, China

4.

Department of Gastroenterology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital600 Yi Shan Road, Shanghai, China

Turk J Gastroenterol 2014; 25: 69-74
DOI: 10.5152/tjg.2014.6611
Read: 639 Downloads: 112 Published: 25 July 2019

Abstract

Background/Aims: To investigate whether temporary placement of a paclitaxel or rapamycin eluting stent is more effective to reduce stenting induced inflammatory reaction and scaring than a bared stent in benign cardia stricture models.

 

Materials and Methods: Eighty dog models of stricture were randomly divided into a control group (CG, n=20, no stent insertion), a bare stent group (BSG, n=20), a paclitaxel eluting (Pacl-ESG, n=20) and a rapamycin eluting stent group (Rapa-ESG, n=20), with one-week stent retention. Lower-oesophageal-sphincter pressure (LOSP), 5-minute barium height (5-mBH) and cardia diameter were assessed before, immediately after the procedure, and regularly for 6 months. Five dogs in each group were euthanized for histological examination at each follow-up assessment.

 

Results: Stent insertion was well tolerated, with similar migration rates in three groups. At 6 months, LOSP and 5-mBH improved in Pacl-ESG and Rapa-ESG compared to BSG (p<0.05), with no difference between Pacl-ESG and Rapa-ESG (p>0.05). Cardia kept more patency in the Pacl-ESG and Rapa-ESG than in BSG (p<0.05). Reduced peak inflammatory reactions and scarring occurred in the Pacl-ESG and Rapa-ESG compared to BSG (p<0.05), with a similar outcome in the Pacl-ESG and Rapa-ESG (p>0.05).

 

 

Conclusion: Paclitaxel or rapamycin-eluting stents insertion led to better outcomes than bare stents in benign cardia stricture models. 

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EISSN 2148-5607