Turkish Journal of Gastroenterology
Original Article

Routinely evaluated clinical assays and laboratory tests [real test] and fibrosis stages of chronic hepatitis B and C

1.

Department of Gastroenterohepatology, Bezmialem Vakif University Faculty of Medicine, İstanbul, Turkey

2.

Department of Gastroenterohepatology, Selçuk University Faculty of Medicine, Konya, Turkey

3.

Department of Gastroenterohepatology, Necmettin Erbakan University Faculty of Medicine, Konya, Turkey

4.

Department of Gastroenterohepatology, Osmangazi University Faculty of Medicine, Eskişehir, Turkey

5.

Department of Gastroenterohepatology, Başkent University Faculty of Medicine, Konya, Turkey

6.

Department of Gastroenterohepatology, İstanbul University Cerrahpaşa Faculty of Medicine, İstanbul, Turkey

7.

Department of Gastroenterohepatology, İstanbul University İstanbul Faculty of Medicine, İstanbul, Turkey

Turk J Gastroenterol 2014; 25: 539-545
DOI: 10.5152/tjg.2014.6170
Read: 502 Downloads: 96 Published: 25 July 2019

Abstract

Background/Aims: To provide a new mathematical formula to predict liver fibrosis in patients with chronic viral hepatitis.

 

Materials and Methods: Patients with chronic hepatitis B and C who underwent liver biopsy at different centers were included in this study. Chronic hepatitis B was defined as immunopositivity for the hepatitis B surface antigen for at least 6 months, and chronic hepatitis C was defined as positivity for HCV RNA for at least 3 months. The histological features were evaluated by the histological activity index and fibrosis.

 

Results: In total, 1299 patients were included in the study. The distribution and the mean of the parameters of the patients were as follows: 1009 patients with chronic hepatitis B with a mean age of 45±13/years [emale/male (F/M)=47.5/52.5%] and 290 patients with hepatitis C with a mean age of 52±10.3/years [F/M=61/39%]. When the cut-off value of the REAL TEST formula“[(age x pT x AST)/(PLT/1000)]/100” in patients with hepatitis B was determined to be ≥1.37, it was found that it could predict fibrosis with 79% specificity, 78% sensitivity, 85% negative predictive value (NPV), and 70% positive predictive value (PPV) (area under the curve (AUC)=0.852, 95% CI:0.82-0.87). When the cut-off value of the REAL TEST formula in patients with hepatitis C was determined to be ≥1.99, it was found that it could predict significant fibrosis with 87% specificity, 90% sensitivity, 94.4% NPV, and 79.4% PPV (AUC:0.95, 95% CI:0.93-0.98)

 

Conclusion: The REAL TEST formula results correlated with the pathological findings and may be a useful method for the evaluation of patients with chronic hepatitis B and C.

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EISSN 2148-5607