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Gastrointestinal Tract - Original Article

Role of toll-like receptor 10 gene polymorphism and gastric mucosal pattern in patients with chronic gastritis

Taweesak Tongtawee 1 , Theeraya Bartpho 1 , Wareeporn Wattanawongdon 1 , Chavaboon Dechsukhum 2 , Wilairat Leeanansaksiri 3 , Likit Matrakool 4 , Sukij Panpimanmas 1
1.

Department of Surgery, Suranaree University of Technology, Institute of Medicine, Nakhon Ratchasima, Thailand

2.

Department of Pathology, Suranaree University of Technology, Institute of Medicine, Nakhon Ratchasima, Thailand

3.

Department of Preclinic, Suranaree University of Technology, Institute of Science, Nakhon Ratchasima, Thailand

4.

Suranaree University of Technology Hospital, Nakhon Ratchasima, Thailand

Turk J Gastroenterol 2017; 28: 243-247
DOI: 10.5152/tjg.2017.16673
Keywords : Toll-like receptor 10, genetic polymorphism, Helicobacter pylori, gastric mucosal pattern
Read: 2270 Downloads: 893 Published: 25 July 2019
Volume 28, Issue 4, July 2017
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Abstract

Background/Aims: Helicobacter pylori stimulates the host’s toll-like receptors (TLRs). Single-nucleotide polymorphism (SNP) of TLRs is related to the manipulation of regulatory cytokines and also implicated in the varied outcomes of the inflammatory response, including the development of precancerous lesions of gastric mucosa and disease progression. We hypothesized that TLR10 rs10004195 polymorphism is associated with gastric mucosal patterns.

 

Materials and Methods: TLR10 rs10004195 polymorphisms were identified in a total of 400 gastritis patients using the TagMan SNP genotyping assay. Gastric mucosal patterns were classified by Conventional Narrow Band Imaging gastroscopy (C-NBI gastroscopy). Logistic regression was used to analyze the association.

 

Results: The gastritis patients was Type 1, 37.5% of Thai patients. The T/T homozygous genotype was exhibited by the highest percentage (46.5%) of patients, and the A/A homozygous and A/T heterozygous genotypes were exhibited by 20.25% and 33.25%, respectively, of patients. TLR10 rs10004195 was significantly associated with gastric mucosal patterns. After adjusting for confounding factors, patients with the A/A homozygous genotype showed a significantly increased risk of severe inflammation (OR=1.35, 95% CI=0.97-2.13, p=0.028). Patients with the A/T heterozygous and T/T homozygous genotypes showed a significantly increased risk of mild inflammation (OR=1.24, 95% CI=0.78-2.07, p=0.042 and OR=1.78, 95% CI=0.51-3.35, p=0.001, respectively).

 

 

Conclusion: Our results indicate that the presence of TLR10 rs10004195, A/T heterozygous, and T/T homozygous genotypes is associated with type 1, 2, and 3 whereas that of the A/A homozygous genotype is associated with type 4 and 5 of gastric mucosal patterns. This suggests that the A/A homozygous genotype contributes to severe inflammation in H. pylori-associated gastritis in Thai patients. 

 

Cite this article as: Tongtawee T, Bartpho T, Wattanawongdon W, et al. Role of toll-like receptor 10 gene polymorphism and gastric mucosal pattern in patients with chronic gastritis. Turk J Gastroenterol  2017; 28: 243-7.

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