Turkish Journal of Gastroenterology
Gastrointestinal Tract - Original Article

Risk Factors for Vitamin D Deficiency in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

1.

Department of Gastroenterology, Zhongshan Hospital Xiamen University, Xiamen, Fujian Province, People’s Republic of China

2.

Department of Nephrology, Zhongshan Hospital Xiamen University, Xiamen, Fujian Province, People’s Republic of China

Turk J Gastroenterol 2021; 32: 508-518
DOI: 10.5152/tjg.2021.20614
Read: 258 Downloads: 68 Published: 02 August 2021

Background: To identify risk factors for hypovitaminosis D in inflammatory bowel disease and conduct a comprehensive systematic review with meta-analysis to quantify the impact on vitamin D deficiency.

Methods: We conducted a literature search of studies through PubMed, Embase, Cochrane Library, and Web of Science. In addition, relevant articles were searched manually. Studies were included if the odds ratios (OR) and 95% CI of each risk factor were reported or could be calculated. We will use the fixed-effects or random-effects model to estimate the pooled effect.

Results: Out of 1018 articles, 25 eligible studies were identified, including 5826 participants. The risk factors associated with hypovitaminosis D were non-Caucasian (OR: 3.79, 95% CI: 2.68-5.34), Crohn’s disease (OR: 1.38, 95% CI: 1.21-1.56), disease activity (OR: 1.85, 95% CI: 1.61-2.13), inflammatory bowel disease-related surgery (OR: 1.61, 95% CI: 1.38-1.89), exposure to steroid (OR: 1.61, 95% CI: 1.28-2.03), and biologics (OR: 1.78, 95% CI: 1.48-2.14). In 30 ng/mL and adjusted OR subgroup, male (OR: 1.84, 95% CI: 1.47-2.31) and winter season (OR: 2.49, 95% CI: 1.69-3.67) also were risk factors, respectively. 5-aminosalicylic acid (OR: 1.10, 95% CI: 0.74-1.63) and smoking (OR: 1.19, 95% CI: 0.98-1.45) were unrelated to vitamin D deficiency.

Conclusions: For vitamin D deficiency in inflammatory bowel disease, non-Caucasian, Crohn’s disease, disease activity, surgery, exposure to steroid and biologics, males are risk factors, while 5-aminosalicylic acid and smoking are not. The relationship between body mass index, winter season, exposure to immunomodulators, and vitamin D deficiency remains unclear.

Cite this article as: Shi S, Feng J, Zhou L, Li Y, Shi H. Risk factors for vitamin d deficiency in inflammatory bowel disease: A systematic review and meta-analysis. Turk J Gastroenterol. 2021; 32(6): 508-518.

Files
EISSN 2148-5607