Turkish Journal of Gastroenterology

Recommendations for Hepatitis B Immunoglobulin and Antiviral Prophylaxis Against Hepatitis B Recurrence After Liver Transplantation


Department of Gastroenterology, Dokuz Eylül University School of Medicine, İzmir, Turkey


Department of Gastroenterology, Ege University School of Medicine, Izmir, Turkey


Department of Gastroenterology, University of Health Sciences, Umraniye Training and Research Hospital, Istanbul, Turkey


Department of Gastroenterology, University of Health Sciences, Ankara City Hospital, Ankara, Turkey


Department of Gastroenterology, Koc University School of Medicine, Istanbul, Turkey


Department of Gastroenterology, Turgut Özal University School of Medicine, Malatya, Turkey


Department of Gastroenterology, Hacettepe University School of Medicine, Ankara, Turkey


Center for Organ Transplantation, Medipol University Hospital, Istanbul, Turkey


Department of Gastroenterology, Ankara University School of Medicine, Ankara, Turkey


Department of Gastroenterology, Liver Transplantation Institute, İnönü University School of Medicine, Malatya, Turkey


Department of Gastroenterology, Güven Hospital, Ankara, Turkey


Department of Gastroenterology, Uludag University School of Medicine, Bursa, Turkey

Turk J Gastroenterol 2021; 32: 712-719
DOI: 10.5152/tjg.2021.21608
Read: 1362 Downloads: 561 Published: 01 September 2021

The combination of hepatitis B immunoglobulin and potent nucleos(t)ide analogs after liver transplantation is considered as the standard of care for prophylaxis against hepatitis B virus recurrence. However, the recommended doses, route of administration, and duration of HBIG administration remain unclear. Moreover, hepatitis B immunoglobulin-free prophylaxis with potent nucleos(t)ide analogs has shown promising disease outcomes in preventing hepatitis B virus recurrence. The current recommendations, produced by the Turkish Association for the Study of the Liver, Acute Liver Failure and Liver Transplantation Special Interest Group, suggest a reduced need for hepatitis B immunoglobulin administration with effective long-term suppression of hepatitis B virus replication using potent nucleos(t) ide analogs after liver transplantation.

Cite this article as: Akarsu M, Onem S, Turan I, et al. Recommendations for hepatitis B immunoglobulin and antiviral prophylaxis against hepatitis B recurrence after liver transplantation. Turk J Gastroenterol. 2021; 32(9): 712-719.

EISSN 2148-5607