Turkish Journal of Gastroenterology
Liver - Original Article

Prospective randomized single-blind study of post-operative bleeding after minor oral surgery in patients with cirrhosis


Department of Oral Surgery, Ege University School of Dentistry, İzmir, Turkey


Department of Gastroenterology, Ege University School of Medicine, İzmir, Turkey


Department of Statistics, Ege University School of Science, İzmir, Turkey

Turk J Gastroenterol 2019; 30: 171-176
DOI: 10.5152/tjg.2018.18078
Read: 2567 Downloads: 770 Published: 25 July 2019



Background/Aims: The management of patients with cirrhosis requiring dental extractions is complicated due to an increased risk of post-operative bleeding. Topical hemostatic agents are usually required to control bleeding in these cases, as an adjunct to systemic measures of hemostasis. The aims of this randomized, prospective, single-blind clinical study are twofold. The primary aim is to compare the hemostatic efficacy of chitosan and surgicel in patients with cirrhosis after a tooth extraction, and the secondary aim is to assess the value of the current setting as a clinical model of post-operative bleeding following minor oral surgery.


Material and Methods: Fifty patients with cirrhosis scheduled for a tooth extraction under local anesthesia were prospectively included in the study in a randomized fashion. Patients were blinded to the treatment group they were in. The cirrhosis classification, bleeding time, trauma score, and corrected bleeding time (during post-operative reviews) were recorded. Statistical evaluations were done.


Results: Study groups had an equal number of teeth extractions (40 teeth each). There were no statistically significant differences between the groups with respect to patient demographics, cirrhosis classification, trauma score, and bleeding time. No side effects were noted.


Conclusion: Both Celox and Surgicel are effective for controlling bleeding and are safe after a tooth extraction in patients with cirrhosis.


Cite this article as: Efeoğlu C, Sipahi Çalış A, Karasu Z, Koca H, Boyazıoğlu H. Prospective randomized single-blind study of post-operative bleeding after minor oral surgery in patients with cirrhosis. Turk J Gastroenterol 2019; 30(2): 171-6.

EISSN 2148-5607