Turkish Journal of Gastroenterology
Original Article

Promotional effect of nonalcoholic fatty liver disease on Gallstone disease: A systematic review and meta-analysis


Institute for Viral Hepatitis, Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), The Second Affiliated Hospital of Chongqing Medical University, Chongqing, PR, China


Department of Clinical Nutrition, Beijing Tsinghua Changgung Hospital Medical Center, Tsinghua University, Beijing, China


Department of Clinical Nutrition, the Second Affiliated Hospital of Chongqing Medical University, Chongqing, China

Turk J Gastroenterol 2017; 28: 31-39
DOI: 10.5152/tjg.2016.0357
Read: 2538 Downloads: 832 Published: 25 July 2019


Background/Aims: Growing evidence indicates that nonalcoholic fatty liver disease (NAFLD) and gallstone disease (GD) share the same risk factors, and that NAFLD may be associated with the occurrence of GD. However, overall results remain controversial. The aim of this study is to perform a meta-analysis to assess the relationship between GD and NAFLD.


Materials and Methods: Five databases (PubMed, Medline, Embase, Web of Science, and Cochrane Library) were queried, and observational studies that assessed the association between GD and NAFLD were selected. We pooled the prevalence of GD in participants with NAFLD, and compared the prevalence of GD in NAFLD and non-NAFLD groups in four trials.


Results: Twelve studies met our inclusion criteria. The pooled prevalence of GD in cases with NAFLD was 17% (95% CI: 0.12–0.23). Compared with the non-NAFLD group, NAFLD was significantly correlated with GD (OR: 1.40, 95% CI: 1.23–1.59). Additional analyses reveal that participants in the GD group included more females (OR: 1.95, 95% CI: 1.36–2.79), were older (WMD: 6.61, 95% CI: 3.80–9.42), and had higher BMIs (WMD: 1.63, 95% CI: 0.62–2.65) in the population with NAFLD, compared to the non-GD group.


Conclusion: GD prevalence in NAFLD patients is higher than that in the general population. Furthermore, the occurrence of GD is significantly associated with the female sex, age and BMI in NAFLD patients. 

EISSN 2148-5607