Turkish Journal of Gastroenterology
Original Article

Prevalence of Pancreatic Steatosis and Its Associated Factors in Turkey: A Nation-Wide Multicenter Study

1.

Department of Gastroenterology, Mersin University Faculty of Medicine, Mersin, Turkey

2.

Department of Gastroenterology, Gazi University Faculty of Medicine, Ankara, Turkey

3.

Department of Gastroenterology, Manisa Celal Bayar University Faculty of Medicine, Manisa, Turkey

4.

Department of Gastroenterology, Acıbadem Mehmet Ali Aydınlar University Faculty of Medicine, İstanbul, Turkey

5.

Department of Gastroenterology, Sakarya University Faculty of Medicine, Sakarya, Turkey

6.

Department of Gastroenterology, Memorial Bahçelievler Hospital, University of Gaziantep Faculty of Medicine, İstanbul, Turkey

7.

Department of Medicine, Johns Hopkins Hospital and Health System, Baltimore, Maryland, USA

8.

Department of Gastroenterology, Ege University Faculty of Medicine, İzmir, Turkey

9.

Department of Gastroenterology, Dokuz Eylül University Faculty of Medicine, İzmir, Turkey

10.

Department of Gastroenterology, Yüksek İhtisas Education and Research Hospital, Ankara, Turkey

11.

Department of Gastroenterology, Dicle University Faculty of Medicine, Diyarbakır, Turkey

12.

Department of Gastroenterology, İstanbul Kanuni Sultan Süleyman Training and Research Hospital, İstanbul, Turkey

13.

Department of Gastroenterology, University of Health Science Okmeydanı Training and Research Hospital, İstanbul, Turkey

14.

Department of Gastroenterology, Gaziosmanpaşa Taksim Education and Research Hospital, İstanbul, Turkey

15.

Department of Gastroenterology, Ministry of Health Amasya Sabuncuoğlu Şerefeddin Education and Research Hospital, Amasya, Turkey

16.

Department of Gastroenterology, Şanlıurfa Mehmet Akif İnan Education and Research Hospital, Şanlıurfa, Turkey

17.

Department of Gastroenterology, University of Gaziantep, Gaziantep, Turkey

18.

Department of Gastroenterology, Yüksek İhtisas Education and Research Hospital, Ankara, Turkey

19.

Department of Gastroenterology, Kırıkkale University Faculty of Medicine, Kırıkkale, Turkey

Turk J Gastroenterol 2024; 35: 239-254
DOI: 10.5152/tjg.2024.23583
Read: 920 Downloads: 480 Published: 04 March 2024

Background/Aims: Pancreatic steatosis (PS) is a pathology associated with metabolic syndrome (MS), endocrin and exocrine disfunctions of the pancreas, and fatty liver. The data on the frequency of PS are very limited. We aimed to evaluate the frequency of PS detected by transabdominal ultrasonography (TAU) in gastroenterology clinics located in different geographical regions of Turkey and the factors associated with it.

Materials and Methods: Volunteers were evaluated by TAU for PS and hepatosteatosis (HS), and its degree. Pancreatic stiffness was evaluated by ultrasonographic shear wave elastography (SWE). All demographic, physical, and biochemical parametres were measured.

Results: A total of 1700 volunteers from 14 centers throughout Turkey were included in the study. Mean age was 48.03 ± 20.86 years (56.9% female). Prevalance of PS was detected in 68.9%. In the PS group, age, body mass index (BMI), waist circumference, systolic blood pressure, fasting blood glucose (FBG), lipid levels, insulin resistance, diabetes mellitus, hypertension, MS frequency, and pancreatic SWE score were increasing, and fecal elastase level was decreasing in correlation with the degree of PS. The frequency of HS was 55.5%. Hepatosteatosis [odds ratio (OR): 9.472], increased age (OR: 1.02), and BMI (OR: 1.089) were independent risk factors for the occurrence of PS. Lean-PS rate was 11.8%. The lean-PS group was predominantly female and younger than non-lean PS. Also it has lower blood pressure, FBG, liver enzymes, lipid levels, and HS rates.

Conclusion: The frequency of PS was found 68.9% in Turkey. Its relationship was determined with age, BMI, HS, MS (and its components), pancreatic stiffness, and fecal elastase level. Keywords: Elastography, exocrine pancreatic insufficiency, lean steatosis, pancreas stiffness, pancreatic steatosis, ultrasonography

Cite this article as: Sezgin O, Yaraş S, Cindoruk M, et al. Prevalence of pancreatic steatosis and its associated factors in Turkey: A nation-wide multicenter study. Turk J Gastroenterol. 2024;35(3):239-254.

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