Turkish Journal of Gastroenterology
Gastrointestinal Tract - Original Article

Polidocanol versus phenol in oil injection sclerotherapy in treatment of internal hemorrhoids: A randomized controlled trial


Department of Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India

Turk J Gastroenterol 2020; 31: 378-383
DOI: 10.5152/tjg.2020.19276
Read: 163 Downloads: 71 Published: 02 June 2020

Background/Aims: Management of Haemorrhoids is suboptimal and is largely based on traditional practices in the Indian population. Though injection sclerotherapy is a well-accepted treatment modality in early grade haemorrhoids, there is no consensus on the effectiveness of the drugs used for sclerotherapy. The study was done to compare the safety and efficacy of a standard sclerosant (polidocanol) and the conventionally used phenol in oil in bleeding grade-1 and 2 internal haemorrhoids.

Materials and Methods: All patients with grade-1 and 2 hemorrhoids, were selected and randomised into two groups, 3% polidocanol and 5% phenol group. All patients were followed-up for three months and observed for “free of bleeding” or “persistent bleeding.” Pain, pruritus and patient satisfaction following the procedure was also assessed.

Results: A total of 150 patients were enrolled, 75 in each group. At the end of the first sclerotherapy session with polidocanol, 60.6% of patients versus 38.1% in phenol group had stopped per rectal bleeding (p=0.009). After the second sclerotherapy session, 94.7% of patients in the polidocanol group and 84% of patients in the phenol group were treated successfully. Polidocanol group required significantly fewer treatment sessions than the phenol group (1.39±0.49 vs. 1.62±0.49; p=0.035), and the total volume of injected sclerosant was also less (3.30±0.96 mL vs. 4.86±1.46 mL; p=0.001). The patient satisfaction was 87% in polidocanol group versus 73% in phenol group (p=0.040).

Conclusion: 3% polidocanol is safe and more effective than 5% phenol in oil when used as injection sclerotherapy in the treatment of first and second-degree internal hemorrhoids.

Cite this article as: Mishra S, Sahoo AK, Elamurugan TP, Jagdish S. Polidocanol versus Phenol in Oil Injection Sclerotherapy in Treatment of Internal Haemorrhoids: A Randomized Controlled Trial. Turk J Gastroenterol 2020; 5: 378-83.

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