Turkish Journal of Gastroenterology
Original Article

Mucocutaneous Manifestations and Associated Factors in Patients with Crohn’s Disease

1.

Division of Gastroenterology, Department of Internal Medicine, Van Teaching and Research Hospital, Health Sciences University, Van, Turkey

2.

Department of Internal Medicine, Van Teaching and Research Hospital, Health Sciences University, Van, Turkey

3.

Division of Gastroenterology, Department of Pediatrics, Van Teaching and Research Hospital, Health Sciences University, Van, Turkey

4.

Department of Biomedical Engineering, İstanbul University, İstanbul, Turkey

5.

Division of Gastroenterology, Department of Internal Medicine, Koç University, İstanbul, Turkey

6.

Department of Gastroenterology, İstanbul University İstanbul Faculty of Medicine, İstanbul, Turkey

Turk J Gastroenterol 2022; 33: 945-954
DOI: 10.5152/tjg.2022.21750
Read: 192 Downloads: 48 Published: 01 November 2022

Background: One-third of all extraintestinal manifestations are mucocutaneous findings in patients with Crohn’s disease and there is a relationship between some risk factors. Our aim is to evaluate factors associated with mucocutaneous manifestations in our cohort of patients with Crohn’s disease with a follow-up duration of up to 25 years.

Methods: In the study, 336 patients with Crohn’s disease who were followed up between March 1986 and October 2011 were included. The demographic characteristics, Crohn’s disease-related data, and accompanying mucocutaneous manifestations were recorded. The cumulative probability of mucocutaneous extraintestinal manifestations and possible risk factors were analyzed.

Results: Oral and skin involvement were detected in 109 (32%) and 31 (9.2%) patients, respectively. The cumulative probability of developing oral and skin manifestations were 43.2% and 20.3%, respectively. Cox regression analysis showed that female gender (odds ratio: 3.28, 95% CI: 1.51-7.14, P = .003) and corticosteroid use (odds ratio: 7.88, 95% CI: 1.07-57.97, P = .043) are independently associated with the development of skin manifestations, while family history (odds ratio: 3.59, 95% CI: 2.18-5.93, P < .001) and inflammatory-type disease (odds ratio: 1.776, 95% CI: 1.21-2.61, P = .004) were independently associated with the development of oral ulcers.

Conclusion: Mucocutaneous extraintestinal manifestations are associated with female gender, corticosteroid use, family history, and disease type in a large cohort of patients with Crohn’s disease. Defining the specific relationships of immune-mediated diseases will help to better understand the pathogenesis of Crohn’s disease and associated mucocutaneous manifestations and to use more effective treatments.

Cite this article as: Kayar Y, Dertli R, Konür S, et al. Mucocutaneous manifestations and associated factors in patients with Crohn’s disease. Turk J Gastroenterol. 2022;33(11):945-954.

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