Turkish Journal of Gastroenterology
Pancreatobiliary - Original Article

Long-term Survival after resection for perihilar cholangiocarcinoma: Impact of UICC staging and surgical procedure

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Department of General, Visceral and Transplantation Surgery, University Duisburg-Essen, University Hospital Essen, Essen, Germany

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-Department of General, Visceral and Transplantation Surgery, University Duisburg-Essen, University Hospital Essen, Essen, Germany;Department of General and Visceral Surgery, St. Bernhard-Hospital Kamp-Lintfort, Kamp-Lintfort, Germany

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Institute of Pathology, University Hospital Essen, University Duisburg-Essen, Essen, Germany

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Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Essen, Germany

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Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke University Magdeburg, Magdeburg, Germany

Turk J Gastroenterol 2019; 30: 454-460
DOI: 10.5152/tjg.2019.18275
Read: 106 Downloads: 6 Published: 25 July 2019

Abstract

 

Background/Aims: Perihilar cholangiocarcinoma is a rare disease with unfavorable prognosis resulting in low survival rates. This study aims to retrospectively assess the beneficial histopathological features and surgical procedures in long-term survivors (i.e., patients surviving perihilar cholangiocarcinoma for at least 2 y).

 

Material and Methods: In total, 322 patients with perihilar cholangiocarcinoma underwent surgery at our center. The follow-up ended in 2017; 76 patients survived for >2 y. The type of resection, UICC stage, and histopathological features were compared between three survival groups (>2-3, >3-5, and >5 y).

 

Results: The >5-year-survival rate in our selected study cohort was 43.4% (>3-5 y,31.6% and >2-3 y, 25.0%), and 14.5% of the patients survived for >10 y after surgery. Patients with non-regional lymph node positive tumors and/or distant metastasis (i.e., UICC stage IVb; p=0.0112), R2 status (p=0.0288), and exploratory laparotomy only (p=0.0157) showed the poorest survival rates. Perineural invasion had no significant impact on the overall survival. However, 29.0% patients surviving for >5 y displayed the lowest perineural infiltration prevalence. Interestingly, Bismuth-Corlette stage IIIa (p=0.0467), especially caudate lobectomy (p=0.0034), was associated with disease-specific overall survival of >5y.

 

Conclusion: Complete/extended tumor resection with additional caudate lobe resection is strongly associated with long-term survival. Perineural infiltration as a negative prognostic marker for prolonged survival needs to be evaluated in larger study cohorts.

 

Cite this article as: Juntermanns B, Kaiser GM, Reis H, et al. Long-term Survival after resection for perihilar cholangiocarcinoma: Impact of UICC staging and a surgical procedure. Turk J Gastroenterol 2019; 30(5): 454-60.

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