Turkish Journal of Gastroenterology

Liver fibrosis


Mikrogen Genetic Diagnostic Laboratory, Ankara, Turkey


Department of Biophysics, Ankara University, School of Medicine, Ankara, Turkey

Turk J Gastroenterol 2018; 29: 14-21
DOI: 10.5152/tjg.2018.17330
Read: 141 Downloads: 15 Published: 25 July 2019


Liver fibrosis is a wound-healing response generated against an insult to the liver that causes liver injury. It has the potential to progress into cirrhosis, and if not prevented, it may lead to liver cancer and liver failure. The activation of hepatic stellate cells (HSCs) is the central event underlying liver fibrosis. In addition to HSCs, numerous studies have supported the potential contribution of bone marrow-derived cells and myofibroblasts to liver fibrosis. The liver is a heterogeneous organ; thus, molecular and cellular events that underlie liver fibrogenesis are complex. This review aims to focus on major events that occur during liver fibrogenesis. In addition, important antifibrotic therapeutic approaches and experimental liver fibrosis models will be discussed.



Cite this article as: Aydın MM, Akçalı KC. Liver fibrosis. Turk J Gastroenterol 2018; 29: 13-20.

EISSN 2148-5607