Turkish Journal of Gastroenterology
Gastrointestinal Tract - Original Article

Levels of TAFI, TFPI and ADAMTS-13 in inflammatory bowel disease


Department of Gastroenterology, Bursa State Hospital, Bursa, Turkey


Department of Gastroenterology, Ondokuz Mayıs University School of Medicine, Samsun, Turkey


Department of Hematology, Bursa Higher Specialization Training and Research Hospital, Bursa, Turkey


Department of Pediatric Gastroenterology, Hepatology and Nutrition, Health Sciences University, Antalya Trainig and Research Hospital, Antalya, Turkey


Department of Gastroenterology, Health Sciences University, Ümraniye Training and Research Hospital, İstanbul, Turkey

Turk J Gastroenterol 2019; 30: 1025-1029
DOI: 10.5152/tjg.2019.19346
Read: 498 Downloads: 260 Published: 18 December 2019

Background/Aims: There is an increased tendency for thrombosis and thromboembolic complications in patients with inflammatory bowel disease (IBD). The aim of the present study was to determine the serum concentrations of thrombin-activatable fibrinolysis inhibitor (TAFI), tissue factor pathway inhibitor (TFPI) and a disintegrin and metalloproteinase with thrombospondin motif-13 (ADAMTS-13) in patients with IBD and to assess their possible role in the etiopathogenesis of the disease.

Materials and Methods: Thirty-four patients with IBD (23 ulcerative colitis and 11 Crohn’s disease) and 20 healthy controls were included in the present study. TAFI, TFPI, and ADAMTS-13 concentrations were determined by enzyme-linked immunosorbent assay.

Results: Mean TAFI, TFPI, and ADAMTS-13 concentrations in the patient group were 17.75 ng/ml, 72.10 ng/ml, and 14.90 U/l, respectively. In the control group, these values were 117.10 ng/ml, 300 ng/ml, and 191.55 U/l, respectively. TAFI, TFPI, and ADAMTS-13 values were significantly lower in the patient group than in the control group (all p<0.01).

Conclusion: TAFI, TFPI, and ADAMTS-13 levels were significantly lower in the patient group. These findings indicate the presence of a clear, multifactorial imbalance in the coagulation–fibrinolytic system in the patient group. It is also possible that this imbalance in the coagulation and fibrinolytic system may play a role in the still unclear etiopathogenesis of the disease.

Cite this article as: Yüzbaşıoğlu B, Ustaoğlu M, Yüzbaşıoğlu Ş, Akbulut UE, Özdil K. Levels of TAFI, TFPI and ADAMTS-13 in inflammatory bowel disease. Turk J Gastroenterol 2019; 30(12): 1025-9.

EISSN 2148-5607