Turkish Journal of Gastroenterology
Pancreatobiliary - Original Article

Level of serum soluble Tim-3 expression in early-phase acute pancreatitis

1.

Department of Gastroenterology, the Affiliated Changzhou No.2 People’s Hospital with Nanjing Medical University, Changzhou, China

2.

Department of Gastroenterology, the First Affiliated Hospital of Soochow University, Suzhou, China

3.

Department of ICU, the First Affiliated Hospital of Soochow University, Suzhou, China

Turk J Gastroenterol 2019; 30: 188-191
DOI: 10.5152/tjg.2018.18137
Read: 49 Downloads: 8 Published: 25 July 2019

Abstract

 

Background/Aims: T-cell immunoglobulin and mucin domain 3 (Tim-3) assumedly play a crucial immunomodulatory role in inflammatory response. Data on the potential role of soluble Tim-3 (sTim-3) in acute pancreatitis (AP) are scarce. We conducted a prospective clinical study to characterize its role in the early-phase AP.

 

Methods: In total, 44 patients with AP (16 mild and 28 none-mild) who presented within 24 hours on admission and 20 healthy volunteers (NC) were included in our study. Serum interleukin (IL)-6, IL-10, tumor necrosis factor (TNF)-α, and sTim-3 levels were detected using enzyme-linked immunosorbent assay (ELISA).

 

Results: Levels of the pro-inflammatory cytokines IL-6 and TNF-α and the anti-inflammatory cytokine IL-10 in the none-mild and mild groups were significantly elevated compared with those of the NC group. The sTim-3 levels of the none-mild and mild group were significantly increased compared with the NC. The sTim-3 level positively correlated with the IL-6 and TNF-α but showed no obvious correlations with the IL-10 level. The sTim-3 level positively correlated with the APACHE II score.

 

Conclusion: The results indicate that sTim-3 participates in the early progression of AP by positively regulating the pro-inflammatory cytokines and that the measurement of serum sTim-3 is an early marker for predicting AP.

 

Cite this article as: Lin M, Huang J, Huang J, Liu SI, Chen WC. Level of serum soluble Tim-3 expression in early-phase acute pancreatitis. Turk J Gastroenterol 2019; 30(2): 188-91.

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