Turkish Journal of Gastroenterology
Original Articles

Investigation of Possible Positive Effects of Arbutin Application in Experimental Colitis Model


Department of Internal Medicine, Adnan Menderes University Faculty of Medicine, Aydın, Turkey


Department of Physiology, Adnan Menderes University Faculty of Medicine, Aydın, Turkey


Department of Gastroenterology, Adnan Menderes University Faculty of Medicine, Aydın, Turkey


Department of Pathology, Adnan Menderes University Faculty of Medicine, Aydın, Turkey

Turk J Gastroenterol 2024; 35: 523-531
DOI: 10.5152/tjg.2024.23205
Read: 305 Downloads: 199 Published: 25 March 2024

Background/Aims: This study aimed to investigate the possible positive effects of arbutin in a trinitrobenzene sulfonic acid (TNBS)- induced experimental colitis model, to compare it with mesalazine, which is used in treating inflammatory bowel disease and to observe the effect of its concomitant use.

Materials and Methods: Forty Wistar albino species male rats were randomized into 5 groups as control, colitis, colitis+arbutin (Arb), colitis+mesalazine (Mes), and colitis+mesalazine+arbutin (M+A). Proinflammatory cytokines [interleukin (IL)-6, IL-1β, tumor necrosis factor alpha (TNF-α)] and oxidant/antioxidant parameters [malondialdehyde (MDA), superoxide dismutase inhibition (SOD) inhibition, myeloperoxidase (MPO), and catalase, glutathione peroxidase (GPx)] were processed from the samples. Histopathological evaluation evaluated goblet cell reduction, cellular infiltration, and mucosal loss.

Results: When the treatment groups and the TNBS group were compared, statistical significance was achieved in MDA, MPO, SOD inhibition, GPx values, IL-6, IL-1β and TNF-α levels. Histopathological evaluation revealed a statistically significant decrease in the mucosal loss value in the group where mesalazine and arbutin were used together compared to the TNBS group.

Conclusion: Our study’s results elaborated that using arbutin alone or in combination with mesalazine produced positive effects in colitis-induced rats.

Cite this article as: Alemdar MB, Şirinyıldız F, Coşkun A, et al. Investigation of possible positive effects of arbutin application in experimental colitis model. Turk J Gastroenterol. 2024;35(7):523-531.

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