Turkish Journal of Gastroenterology
Liver - Original Article

Interferon gamma gene polymorphisms and chronic hepatitis B infections in an Iranian population

1.

Infectious Diseases and Tropical Medicine Research Center, Resistant Tuberculosis Institute, Zahedan University of Medical Sciences, Zahedan, Iran

2.

Department of Histology, Zahedan University of Medical Sciences, Zahedan, Iran

Turk J Gastroenterol 2020; 31: 515-521
DOI: 10.5152/tjg.2020.181024
Read: 228 Downloads: 95 Published: 30 April 2020

Background and Aims: Chronic hepatitis B is an important health problem in all countries. I Interferon gamma is a pro-inflammatory Th1 cytokines, which can exert antiproliferative and antitumor activity. Some SNPs in IFN-γ and IFN-γR1 genes may influence the susceptibility to HBV. Here, we evaluated the impact of interferon gamma (+874 T/A) and its receptor (-611A/G, +189G/C and +95C/T) polymorphisms and the risk of HBV in Iranian patients.

Materials and Methods: SNPs of interferon gamma and its receptor genotypes were determined in 221 infected patients with HBV and 200 people without HBV using ARMS-PCR and PCR- RFLP method.

Results: In this study, we showed an obvious relationship between IFN-γ SNPs and susceptibility to chronic HBV. Our findings suggest that IFN-γ-874A allele increases the risk of disease and carriers of the T allele have reduced susceptibility to infection. In addition, there was not any relationship between the -611A/G, +189G/C and +95C/T regions of IFN-γ R1 and HBV.

Conclusions: Our observations demonstrate +874 T/A SNP as a predicting factor in patients who have the risk of HBV.

Cite this article as: Heidari Z, Moudi B, Mahmoudzadeh-Sagheb H. Interferon gamma gene polymorphisms and chronic hepatitis B infections in Iranian population. Turk J Gastroenterol 2020; 31(7): 515-21.

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