Turkish Journal of Gastroenterology
Liver - Original Article

Infections developing in patients undergoing liver transplantation: Recipients of living donors may be more prone to bacterial/fungal infections

1.

Department of Infectious Diseases and Clinical Microbiology, Ege University School of Medicine, Bornova, Izmir, Turkey

2.

Department of General Surgery, Ege University School of Medicine, Bornova, Izmir, Turkey

3.

Department of Medical Microbiology, Ege University School of Medicine, Bornova, Izmir, Turkey

4.

Department of Pediatric Surgery, Ege University School of Medicine, Bornova, Izmir, Turkey

5.

Division of Paediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Ege University School of Medicine, Bornova, Izmir, Turkey

6.

Department of Gastroenterology, Ege University School of Medicine, Bornova, Izmir, Turkey

7.

Department of Anaesthesiology and Reanimation, Ege University School of Medicine, Bornova, Izmir, Turkey

8.

Department of Pathology, Ege University School of Medicine, Bornova, Izmir, Turkey

9.

Department of Radiology, Ege University School of Medicine, Bornova, Izmir, Turkey

10.

Director of Transplantation Council, Ege University School of Medicine, Izmir, Turkey

Turk J Gastroenterol 2020; 31: 894-901
DOI: 10.5152/tjg.2020.19286
Read: 96 Downloads: 62 Published: 04 May 2020

Background/Aims: Despite surgical advances in liver transplantation and effective prophylactic strategies, posttransplant infections are the most important cause of morbidity and mortality. Diagnosis and management of infections because of developing immunosuppression is difficult and adversely affects mortality. This study aimed to review bacterial and fungal infections in patients after liver transplantation and to reveal the resistance rates.

Materials and Methods: A total of 107 patients who underwent liver transplantation between January 2017 and February 2018 were evaluated retrospectively with regard to demographic characteristics, causes of transplantation, conditions that may lead to infection, postoperative infections, pathogens, and resistance patterns.

Results: Of the 107 patients who underwent liver transplantation, 48 (44.8%) had an infection. Bacterial infections were detected in 41% of the patients, and fungal infections were found in 13%. When we compared living and cadaveric transplants in terms of infection development, these rates were found to be 53% and 33%, respectively (p=0.034). No statistically significant results could be obtained when evaluating conditions such as sex, presence of underlying primary disease, Model for End-Stage Liver Disease MELD score, diabetes status, total parenteral nutrition, and risk factors for infection.

Conclusion: After liver transplantation, infections are often seen in the first month of the postoperative period. Knowing the most common pathogens and resistance states in this process reduces infection-related deaths by providing appropriate treatment regimens at the right time. 

Cite this article as: Yamazhan T, Bulut Avşar C, Zeytunlu M, et al. Infections developing in patients undergoing liver transplantation: Recipients of living donors may be more prone to bacterial/fungal infection. Turk J Gastroenterol 2020; 31(12): 894-901.

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