Turkish Journal of Gastroenterology
Original Article

High-resolution manometry: Reliability of automated analysis of upper esophageal sphincter relaxation parameters

1.

Institute for Digestive Research, Digestive Disease Center, Soonchunhyang University College of Medicine, Seoul, Republic of Korea

2.

Department of Internal Medicine, Soonchunhyang University College of Medicine, Bucheon, Republic of Korea

3.

Biostatistical Consulting Unit, Soonchunhyang University College of Medicine, Seoul, Republic of Korea

4.

Department of Internal Medicine, Soonchunhyang University Hospital, Gumi, Republic of Korea

5.

Department of Physical Medicine and Rehabilitation, Soonchunhyang University College of Medicine, Seoul, Republic of Korea

Turk J Gastroenterol 2014; 25: 473-480
DOI: 10.5152/tjg.2014.8021
Read: 604 Downloads: 179 Published: 25 July 2019

Abstract

Background/Aims: At present, automated analysis of high-resolution manometry (HRM) provides details of upper esophageal sphincter (UES) relaxation parameters. The aim of this study was to assess the accuracy of automatic analysis of UES relaxation parameters.

 

Materials and Methods: One hundred and fifty three subjects (78 males, mean age 68.6 years, range 26-97) underwent HRM. UES relaxation parameters were interpreted twice, once visually (V) by two experts and once automatically (AS) using the ManoView ESO analysis software. Agreement between the two analysis methods was assessed using Bland-Altman plots and Lin’s concordance correlation coefficient (CCC).

 

Results: The agreement between V and AS analyses of basal UES pressure (CCC 0.996; 95% confidence interval (CI) 0.994-0.997) and residual UES pressure (CCC 0.918; 95% CI 0.895-0.936) was good to excellent. Agreement for time to UES relaxation nadir (CCC 0.208; 95% CI 0.068-0.339) and UES relaxation duration (CCC 0.286; 95% CI 0.148-0.413) between V and AS analyses was poor. There was moderate agreement for recovery time of UES relaxation (CCC 0.522; 95% CI 0.397-0.627) and peak pharyngeal pressure (CCC 0.695; 95% CI 0.605-0.767) between V and AS analysis.

 

Conclusion: AS analysis was unreliable, especially regarding the time variables of UES relaxation. Due to the difference in the clinical interpretation of pharyngoesophageal dysfunction between V and AS analysis, the use of visual analysis is justified.

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