Turkish Journal of Gastroenterology
Original Article

Healthcare-Related HCV Genotype 4d Infections in Kayseri, Turkey


Department of Medical Microbiology, Erciyes University Faculty of Medicine, Kayseri, Turkey


Department of Medical Microbiology, Hacettepe University Faculty of Medicine, Ankara, Turkey


Erciyes University Medical Faculty Department of Gastroenterology, Turkey


Department of Public Health, Dokuz Eylül University Faculty of Medicine, İzmir, Izmir, Turkey


Department of Infectious Diseases, Erciyes University Faculty of Medicine, Kayseri, Turkey


Department of Gastroenterology, Erciyes University Faculty of Medicine, Kayseri, Turkey


Department of Medical Microbiology, İzmir University of Economics Faculty of Medicine, İzmir, Turkey

Turk J Gastroenterol 2022; 33: 964-970
DOI: 10.5152/tjg.2022.21822
Read: 881 Downloads: 343 Published: 01 November 2022

Background: The frequency of genotype 4 hepatitis C virus infection is significantly higher in a city compared to other provinces in Turkey. In this study, we aimed to investigate the epidemiology and risk factors of hepatitis C virus genotype 4 infection in Kayseri province of Turkey.

Methods: A case–control study was conducted with 61 hepatitis C virus genotype 4-infected patients and 71 controls. A questionnaire was administered to the patients and controls, asking for information about the risk factors of hepatitis C virus transmission. Core/ E1 and NS5B regions of hepatitis C virus genome were amplified and sequenced by Sanger method. Phylogenetic analysis and molecular clock analysis were performed. The risk was determined by calculating the odds ratio and 95% CI. Logistic regression analysis was performed to determine the effect of risk factors by controlling for confounding variables.

Results: Kayseri isolates were closely related to type 4d sequences but formed a separate cluster. According to the molecular clock analysis, hepatitis C virus genotype 4d entered Kayseri province probably between 1941 and 1988. Blood transfusion and surgical intervention were found to be significant risk factors for the infection.

Conclusion: Epidemiological data showed that hepatitis C virus genotype 4d infections are significantly associated with unsafe medical procedures.

Cite this article as: Gökahmetoğlu S, Polat C, Atalay MA, et al. Healthcare-related HCV genotype 4d infections in Kayseri, Turkey. Turk J Gastroenterol. 2022;33(11):964-970.

EISSN 2148-5607