Turkish Journal of Gastroenterology
Original Article

Fatty liver disease might increase the risk of abdominal operation in patients with fatty liver and the prevalence of cancer in first-degree relatives

1.

Department of Gastroenterology, Türkiye Yüksek İhtisas Hospital, Ankara, Turkey

2.

Department of Gastroenterology, İstanbul University Cerrahpaşa Faculty of Medicine, İstanbul, Turkey

3.

Department of Gastroenterology, Bezmialem Vakif University Faculty of Medicine, İstanbul, Turkey

4.

Department of Clinical Microbiology and Infectious Diseases, Medipol University Hospital, İstanbul, Turkey

5.

Department of Gastroenterology, Bezmialem Vakıf University Faculty of Medicine, İstanbul, Turkey

6.

Department of Biostatistics, Bezmialem Vakif University Faculty of Medicine, İstanbul, Turkey

Turk J Gastroenterol 2014; 25: 138-141
DOI: 10.5152/tjg.2014.7674
Read: 373 Downloads: 28 Published: 25 July 2019

Abstract

Background/Aims: We investigated the risk of abdominal operation in patients with fatty liver and the risk of any cancer in first-degree relatives of patients with fatty liver.

 

Materials and Methods: We evaluated 105 patients with nonalcoholic fatty liver disease (NAFLD), 121 patients with biopsy-proven hepatitis C (61 patients with fatty liver and 60 patients without fatty liver), 50 patients with inflammatory bowel disease (IBD), and 109 patients with dyspepsia.

 

Results: There was no difference in sex, mean age, and marital status among the groups except that patients with IBD were younger than the others (p<0.001). The frequency of cancer among family members was 18% in IBD, 9% in dyspepsia, 28% in hepatitis C with steatosis, 21.5% in hepatitis C without steatosis, and 27% in NAFLD (p=0.006). Then, we divided the study group into two groups as follows: group 1: (IBD + dyspepsia + hepatitis C without steatosis) and group 2: (hepatitis C with steatosis + NAFLD). We found that the frequency of cancer was 16% in group 1 versus 24.4 % in group 2 (p=0.037). We also investigated the risk of abdominal operation in patients with fatty liver. The results were as follows: 33% in group without fatty liver versus 43% in group with fatty liver (p=0.043).

 

 

Conclusion: Understanding the underlying causes of fatty liver forms might decrease the cancer frequency in the population and number of operations in patients with fatty liver.

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EISSN 2148-5607
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