Turkish Journal of Gastroenterology
Basic & Translational - Original Article

Efficacy and safety of panitumumab in a cohort of patients with metastatic colorectal cancer in France: PANI OUEST, a post–EMA-approval descriptive study with a geriatric oncology focus

1.

Observatoire dédié au Cancer BPL, siège médical ICO site Paul Papin, France

2.

C.H.R.U., Hôpital Morvan, Institut de cancérologie et d’hématologie, Brest, France

3.

Observatory of Cancer BPL, Angers, France

4.

West Institut of Cancer (ICO), René Gauducheau, Boulevard Jacques Monod, Saint-Herblain, France

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Private Hospital Catherine de Sienne, Nantes, France

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Private Hospital Jean Bernard/Clinique Victor Hugo Le Mans, Le Mans, France

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Hospital Center of Yves le Foll, Saint-Brieuc, France

8.

C.H. Lannion Trestel, Venelle de Kergomar, Lannion, France

9.

Mutualist Clinic of the Estuary, Saint-Nazaire, France

10.

Private Hospital Pasteur-Lanroze, Brest, France

11.

Private Hospital CMC de la Baie de Morlaix, Morlaix, France

12.

C.R.L.C.C. Eugène Marquis, Avenue de la Bataille Flandres-Dunkerque, Rennes, France

13.

Hospital Center B.S, Lorient, France

14.

C.H.P, 6 Boulevard de la Boutière, Saint-Gregoire, France

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Private Hospital Sévigné, Cesson Sevigne, France

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Hospital Center of Vendée, La Roche Sur Yon, France

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Hospital Center of Laval, Laval, France

18.

Hospital Center of Le Mans, Le Mans, France

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Hospital Center of Morlaix, Morlaix, France

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Hospital Center of Laennec, Quimper, France

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West Institut of Cancer (ICO), Paul Papin, Angers, France

22.

Hospital Center of Saumur, Saumur, France

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Hospital Center of Vannes, Vannes, France

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Private Hospital Océane, Vannes, France

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University Hospital of. Nantes Hôtel Dieu, Nantes, France

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Private Hospital CARIO-HPCA, Plerin, France

27.

Hospital Center of. Broussais, Saint-Malo, France

28.

Private Hospital Saint Joseph, Trelaze, France

29.

Brest University Hospital, Brest, France

30.

Brest University Hospital, Institute of Cancerology and Hematology, Brest, France

Turk J Gastroenterol 2020; 31: 695-705
DOI: 10.5152/tjg.2020.19219
Read: 386 Downloads: 258 Published: 30 October 2020

Background/Aims: The Bretagne-Pays de la Loire cancer observatory, an oncology network created by the French Ministry of Health, is specifically dedicated to assess the use of new targeted anticancer therapies in routine practice. In line with the French National Cancer III program, our cancer network set up a real-life cohort, which is independent of the pharmaceutical industry, for patients with colorectal cancer to monitor patient safety and quality of care and promote pharmacovigilance.

Materials and Methods: Panitumumab monotherapy was assessed in 243 patients with wild-type Kirsten rat sarcoma who were treated for metastatic colorectal cancer (mCRC) between July 2008 and December 2010 after prior chemotherapy using oxaliplatine and irinotecan. This was a post–European medicine agency marketing (EMA-M) study

Results: This study shed light on the best practices, strategic adaptations, clinical results (treatment objective responses, 13%; progression free survival, 2.99 months [2.73-3.15]; and overall survival, 6.8 months [5.49-8.38]) as well as expected or unexpected (grade 3 or 4: 11.5%) secondary effects in the phase IV panitumumab treatment of mCRC.

Conclusion: Our results are similar to those by Amado whose phase III study led to obtaining EMA-M for panitumumab and tend to confirm the antitumor activity of this antiepidermal growth factor receptor antibody in the treatment of mCRC. In addition, our results opened avenues to further assessment of panitumumab use as monotherapy as well as its benefit–risk ratio while taking into account the patients’ general and clinical characteristics. In 2012, the French National Authority for Health appended these data to the panitumumab transparency committee report.

Cite this article as: Metges JP, Jean-Yves Douillard JY, Jean-François Ramée JF, et al. Efficacy and safety of panitumumab in a cohort of patients with metastatic colorectal cancer in France: PANI OUEST, a post–EMA-approval descriptive study with a geriatric oncology focus. Turk J Gastroenterol 2020; 31(10): 695-705.

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