Turkish Journal of Gastroenterology
Pediatric Gastroenterology - Original Article

Effects of long-term synbiotic supplementation in addition to lifestyle changes in children with obesity-related non-alcoholic fatty liver disease

1.

Department of Pediatric Gastroenterology, Karadeniz Technical University School of Medicine, Trabzon, Turkey

2.

Department of Pediatrics, Karadeniz Technical University School of Medicine, Trabzon, Turkey

3.

Department of Radiology, Karadeniz Technical University School of Medicine, Trabzon, Turkey

4.

Department of Biochemistry, Karadeniz Technical University School of Medicine, Trabzon, Turkey

5.

Department of Microbiology, Karadeniz Technical University School of Medicine, Trabzon, Turkey

Turk J Gastroenterol 2017; 28: 377-383
DOI: 10.5152/tjg.2017.17084
Read: 616 Downloads: 141 Published: 25 July 2019

Abstract

Background/Aims: We aimed to analyze the efficiency of a novel treatment approach, long-term synbiotic supplementation, in addition to lifestyle changes in children with non-alcoholic fatty liver disease (NAFLD).

 

Materials and Methods: The study included children with NAFLD (n=28) and a healthy control group (n=30). Children with NAFLD were given 1 capsule/day of synbiotics. Anthropometric parameters; biochemical analysis, including ethanol, tumor necrosis factor-α (TNF-α), total oxidant status (TOS) and anti-oxidant status (TAS), zonulin, and fecal calprotectin; and ultrasonographic examination were performed at baseline and 4 months later.

 

Results: The grade of fatty liver was decreased (≥1 grade) in 19 of the 28 patients (67.8%) after synbiotic supplementation. Total cholesterol, low-density lipoprotein (LDL) levels, TNF-α, C-reactive protein (CRP), and ethanol were significantly decreased, and TAS levels were significantly increased at the end of treatment (p<0.05 for all). We found that the median decrease in CRP (-0.16 vs. -0.03 mg/dL, p=0.003) and LDL levels (-17 vs. -3 mg/dL, p=0.019) were higher in patients who responded to the supplementation.

 

 

Conclusion: Synbiotic supplementation in addition to lifestyle changes is effective in children with NAFLD.

 

Cite this article as: Çakır M, İşbilen AA, Eyüpoğlu İ, et al. Effects of long-term synbiotic supplementation in addition to lifestyle changes in children with obesity-related non-alcoholic fatty liver disease. Turk J Gastroenterol 2017; 28: 377-83

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