Turkish Journal of Gastroenterology

Effect of vitamin D levels and osteoporosis on survival in patients with chronic liver disease awaiting liver transplantation


Department of Gastroenterology, Turkiye Yuksek Ihtisas Research and Training Hospital, Ankara, Turkey


Ankara Physical Medicine and Rehabilitation Training and Research Hospital, Ankara, Turkey


Department of Biostatistics, Ankara University, Ankara, Turkey


Department of Gastroenterology, Cukurova University, Adana, Turkey

Turk J Gastroenterol 2019; 30: Supplement 83-84
DOI: 10.5152/tjg.2019.55
Read: 2108 Downloads: 755 Published: 25 July 2019



INTRODUCTION: Chronic liver disease is a risk factor for osteoporosis, osteopenia and bone fractures. In this study, osteoporosis prevalence, risk factors, vitamin D deficiency and effects on survival were investigated in 218 chronic liver disease Turkish patients awaiting liver transplantation retrospectively. 

METHODS: Risk factors for osteoporosis (gender, age, BMI, etiology, smoking, alcohol use), serum bilirubin, albumin, 25-hydroxy (OH)D, parathyroid hormone levels, bone mineral density (BMD) with DEXA, MELD and Child Pugh(CP) scores were recorded. Effects of vitamin D levels and BMD on survival were evaluated. 

RESULTS: 147 (67.4%) patients were female (mean age, 50.4±11.7). Data of the BMD were established in 218 patients and 25-OH D levels in 122 patients. Mean serum 25-OH D level was 14.26±9.44 ng/ml. Osteoporosis was identified in 42 (19.3%) and osteopenia in 115 (52.8%) patients according to BMD (table 1). No statistically difference was found including risk factors, etiology, BMI, CP classification, MELD, albumin, total bilirubin, Ca, PTH between osteoporotic and non-osteoporotic patients. Patients were followed-up for median 30.07±11.83 months after BMD measurement. 54 (24.8%) died during the follow-up period, non of them related bone fracture. There is no statistically difference on survival between osteoporosis group (32.2±2.3 months) and non-osteoporosis group (37.2±1.7 months; p=0.26) (figure1) or between deficieny of vitamin D groups (table 2). 

CONCLUSION: The prevalence of osteoporosis and osteopenia were consistent with the prevalence of osteoporosis reported 12-55% in the literature. Although we didn’t identify any factors that statistically influence the relationship between survival and osteoporosis, cirrhotic patients should be screened for osteoporosis and vitamin D deficiency and treated appropriately.

EISSN 2148-5607