Turkish Journal of Gastroenterology
Original Article

Effect of 3-aminobenzamide on perforation an experimental colitis model

1.

Department of General Surgery, Adana Numune Training and Research Hospital, Adana, Turkey

2.

Department of General Surgery, Güven Hospital, Ankara, Turkey

3.

Department of Medical Biochemistry, Gazi University Faculty of Medicine, Ankara, Turkey

4.

Department of General Surgery, Hitit University Faculty of Medicine, Çorum, Turkey

Turk J Gastroenterol 2014; 25: 86-91
DOI: 10.5152/tjg.2014.4288
Read: 1452 Downloads: 655 Published: 25 July 2019

Abstract

Background/Aims: The anti-inflammatory activity of 3-aminobenzamide (3-AB) has been shown via histopathology and immunohistochemistry in various colitis models. We aimed to study the effects of 3-AB on tissue mechanical endurance and, associatively, preventing perforation in colitis.

 

Materials and Methods: Thirty male Wistar albino rats were randomly divided into three groups. Rectal saline was administered to Group 1 (sham + saline). Rectal trinitrobenzensulphonic acid was applied to induce colitis in Group 2 (colitis + saline) and Group 3 (colitis + 3-AB). Groups 1 and 2 were treated intraperitoneally with saline (1 ml every 12 hours) and Group 3 was treated with 3-AB (10 mg/kg every 12 hours). After seven days, rats were sacrificed and colon lipid peroxidation levels, the serum tumor necrosis factor alpha (TNF-α) level, bowel bursting pressures, and bowel wall tensions were measured.

 

Results: Bowel bursting pressure in Group 2 was significantly lower than in Groups 1 and 3 (p<0.001 for both groups). Bowel wall tension in Group 2 was significantly lower than in Groups 1 and 3 (p<0.001 for both groups). There were no significant differences between groups for serum TNF-α levels. For lipid peroxidation, malondialdehyde (MDA) levels were increased in Groups 2 and 3 compared to Group 1.

 

Conclusion: 3-AB may aid prevention of perforations that develop in inflammatory bowel disease, requiring surgical treatment. 

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