Turkish Journal of Gastroenterology
Pancreatobiliary - Original Article

Dynamic thiol/disulphide homeostasis in acute pancreatitis

1.

Department of Gastroenterology, Ankara Atatürk Training and Research Hospital, Ankara, Turkey

2.

Department of Clinical Biochemistry, Ankara Atatürk Training and Research Hospital, Ankara, Turkey

3.

Department of Gastroenterology, Yıldırım Beyazıt University School of Medicine, Ankara, Turkey

4.

Department of Gastroenterology, Çorlu State Hospital, Tekirdağ, Turkey

Turk J Gastroenterol 2018; 29: 348-353
DOI: 10.5152/tjg.2018.17499
Read: 199 Downloads: 28 Published: 25 July 2019

Abstract

Background/Aims: The dynamic thiol/disulfide homeostasis plays pivotal roles in many physiological mechanisms in an organism. We aimed to investigate whether dynamic thiol/disulfide homeostasis changes among patients with acute pancreatitis.

Materials and Methods: This prospective trial contained 45 patients with acute pancreatitis and 45 sex-and age-matched healthy volunteers as control group. Thiol/disulfide homeostasis parameters were measured by a novel and automated assay, and detected results were compared between the two groups.

Results: Disulfide/total thiol percent ratio and disulfide/native thiol percent ratios were significantly higher in acute pancreatitis group; besides the native thiol, total thiol levels and native thiol/total thiol percent ratios were significantly lower (for all p<0.001).

Conclusion: The thiol/disulfide homeostasis is impaired in acute pancreatitis with a shift toward the oxidative status, and this deficiency might be a pathogenic factor in acute pancreatitis. The correction of this thiol/disulfide imbalance may be a new target in the management of acute pancreatitis.

Cite this article as: Köseoğlu H, Alışık M, Başaran M, et al. Dynamic thiol/disulphide homeostasis in acute pancreatitis. Turk J Gastroenterol 2018; 29: 348-53.

EISSN 2148-5607
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