Turkish Journal of Gastroenterology
Original Article

DR-70 as a novel diagnostic biomarker for gastric cancer

1.

Department of Internal Medicine, Divison of Gastroenterology, Gazi University Faculty of Medicine, Ankara, Turkey

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Department of Internal Medicine, Gazi University Faculty of Medicine, Ankara, Turkey

3.

Department of Medical Biochemistry, Gazi University Faculty of Medicine, Ankara, Turkey

Turk J Gastroenterol 2015; 26: 480-483
DOI: 10.5152/tjg.2015.0425
Read: 431 Downloads: 69 Published: 25 July 2019

Abstract

Background/Aims: To assess the utility of the DR-70 immunoassay in the diagnosis of gastric cancer.

 

Materials and Methods: A total of 29 patients with histologically proven malignant gastric tumor and 29 healthy blood donors were enrolled in this study. DR-70 immunoassay was performed using an enzyme-linked immunosorbent assay kit to quantify the serum levels of fibrin degradation products.

 

Results: The DR-70 values in patients with gastric cancer significantly differed from the values in controls (p<0.0001). Receiver operating characteristic curve analysis revealed ≥1.45 µg/mL as the best cut-off value to distinguish between patients with gastric cancer and healthy controls. The area under the receiver operating characteristic curve was 0.871. Using ≥1.45 µg/mL as the cut-off value, the DR-70 immunoassay showed a good clinical performance with a sensitivity of 82.8% and a specificity of 79.3%. The positive predictive value was 80.0%, and the negative predictive value was 82.1%.

 

Conclusion: The DR-70 immunoassay reliably differs between gastric cancer and healthy controls, promising to become a useful cancer detection tool in clinical practice.

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EISSN 2148-5607
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