Turkish Journal of Gastroenterology
Original Articles

Diagnostic Efficacy of Cell Block and Liquid-Based Cytology for Endoscopic Ultrasound-Guided Fine Needle Aspiration in Pancreatic Tumors

1.

Department of Gastroenterology, University of Health Sciences İzmir Bozyaka Training and Education Hospital, İzmir, Türkiye

2.

Department of Gastroenterology, Bakırçay University Çiğli Training and Education Hospital, İzmir, Türkiye

3.

Department of Pathology, Ege University, Faculty of Medicine, İzmir, Türkiye

4.

Division of Gastroenterology, Department of Internal Medicine, Ege University, Faculty of Medicine, İzmir, Türkiye

Turk J Gastroenterol 2024; 35: 665-674
DOI: 10.5152/tjg.2024.23609
Read: 586 Downloads: 308 Published: 03 July 2024

Background/Aims: This study aimed to evaluate the diagnostic efficacy of cell block (CB) and liquid-based cytology (LBC) for endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) in pancreatic tumors.

Materials and Methods: The study included patients who underwent EUS-FNA for pancreatic tumors between January 2015 and February 2021 and whose cytology samples were both processed for LBC and CB.

Results: Data of 390 patients (220 men, mean age: 64.2 ± 11.4 years) were retrospectively analyzed. Of the detected lesions (size: 17-120 mm; mean: 39.9 ± 13.9 mm), 220 (56.4%) were located in the head and uncinate process of the pancreas. Lesions in 339 (86.9%) patients were diagnosed as malignant using CB and/or LBC and suspicious for malignancy in 44 (11.3%) patients. In 7 patients with non-diagnostic (6 cases) or negative for malignancy (1 case) EUS-FNA results using both methods, the diagnosis of malignancy was established via ultrasound-guided percutaneous biopsy. Malignancy was detected in 324 (92.4%), 313 (87.9%), and 298 (87.9%) patients using CB, LBC, and both CB and LBC, respectively. Final diagnosis was obtained in 339 (98%) patients by using CB and/or LBC. The combined use of the both methods exhibited significantly superior diagnostic accuracy compared with CB and LBC alone (P < .001).

Conclusion: Liquid-based cytology and CB exhibit high diagnostic accuracy for the detection of pancreatic tumors in patients undergoing EUS-FNA. The combined use of both methods showed a significantly higher diagnostic accuracy than LBC and CB alone.

Cite this article as: Şenkaya A, Çelik F, Tekin F, et al. Diagnostic efficacy of cell block and liquid-based cytology for endoscopic ultrasound-guided fine-needle aspiration in pancreatic tumors. Turk J Gastroenterol. 2024;35(8):665-674.

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