Turkish Journal of Gastroenterology
Original Article

Correlation Between Quantitative Hepatitis B Surface Antigen and Hepatitis B Virus Deoxyribonucleic Acid Levels in Hepatitis B e Antigen-Positive and Hepatitis B e AntigenNegative Chronic Hepatitis B Patients

1.

Department of Clinical Pathology, Airlangga University School of Medicine, Dr. Soetomo General Hospital, Surabaya, Indonesia

2.

Department of Clinical Pathology, Brawijaya University School of Medicine, Dr. Saiful Anwar General Hospital, Malang, Indonesia

3.

Division of Gastroentero-hepatology, Department of Internal Medicine, Brawijaya University School of Medicine, Dr. Saiful Anwar General Hospital, Malang, Indonesia

Turk J Gastroenterol 2023; 34: 378-382
DOI: 10.5152/tjg.2020.19612
Read: 1290 Downloads: 583 Published: 01 April 2023

Background: This study aimed to analyze the relationship between quantitative hepatitis B surface antigen and hepatitis B virus deoxyribonucleic acid in hepatitis B e antigen-positive and hepatitis B e antigen-negative chronic hepatitis B patients and to determine the best cut-off value for quantitative hepatitis B surface antigen to predict high hepatitis B virus deoxyribonucleic acid levels (≥2000 IU/mL).

Methods: Ninety-seven sera from chronic hepatitis B patients were collected in this study. Hepatitis B virus deoxyribonucleic acid levels were quantified by real-time polymerase chain reaction. Quantitative hepatitis B surface antigen and hepatitis B e antigen levels were determined by two-site sandwich chemiluminescence immunoassay. Alanine transaminase levels were measured by the International Federation of Clinical Chemistry-approved methods.

Results: A significant correlation between quantitative hepatitis B surface antigen and hepatitis B virus deoxyribonucleic acid levels was observed in hepatitis B e antigen-positive group (r = 0.453, P = .002), but not in hepatitis B e antigen-negative group (r = 0.117, P = .454). No significant correlation between quantitative hepatitis B surface antigen and alanine transaminase was found in the hepatitis B e antigen-positive group (r = 0.521, P = .241). However, a significant correlation was shown between quantitative hepatitis B surface antigen and alanine transaminase levels in the hepatitis B e antigen-negative group (r = 0.455, P = .001). The best cut-off value of quantitative hepatitis B surface antigen for predicting high hepatitis B virus deoxyribonucleic acid levels was 3.422 × 103 IU/mL.

Conclusion: Correlation between quantitative hepatitis B surface antigen and hepatitis B virus deoxyribonucleic acid levels is significant in the hepatitis B e antigen-positive group. Quantitative hepatitis B surface antigen can be used to predict high hepatitis B virus deoxyribonucleic acid levels in the hepatitis B e antigen-positive group

Cite this article as: Nirmala VFI, Aryati A, Susianti H, Mustika S. Correlation between quantitative hepatitis B surface antigen and hepatitis B virus deoxyribonucleic acid levels in hepatitis B e antigen-positive and hepatitis B e antigen-negative chronic hepatitis B patients. Turk J Gastroenterol. 2023;34(4):378-382.

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