Turkish Journal of Gastroenterology
Pancreatobiliary - Original Article

Can pancreatic steatosis affect exocrine functions of pancreas?

1.

Department of Gastroenterology, Yıldırım Beyazıt University School of Medicine, Ankara, Turkey

2.

Department of Radiology, Atatürk Training and Research Hospital, Ankara, Turkey

3.

Department of Gastroenterology, Gazi University School of Medicine, Ankara, Turkey

4.

Department of Biochemistry, Yıldırım Beyazıt University School of Medicine, Ankara, Turkey

5.

Department of Gastroenterology, Atatürk Training and Research Hospital, Ankara, Turkey

Turk J Gastroenterol 2018; 29: 588-594
DOI: 10.5152/tjg.2018.17696
Read: 938 Downloads: 257 Published: 25 July 2019

Abstract

Background/Aims: Pancreatic steatosis (PS) is a generally used term to define accumulation of fat in the pancreas. In theory PS may be able to affect the exocrine function of pancreas. In this study we aimed to determine the effect of PS on exocrine pancreas function.

 

Materials and Methods: Forty-three patients with PS determined by 3 tesla magnetic resonance imaging (MRI) and 48 patients without PS were included in this study. Patients with PS were classified as group 1 and control patients were classified as group 2. Fecal elastase-1 levels were determined. Fecal elastase-1 levels <200 μg/g were defined as exocrine pancreatic insufficiency (EPI). Patients with PS were further grouped according to severity and anatomic distribution of steatosis based on findings of 3 tesla MRI.

 

Results: Fecal elastase-1 levels was significantly lower in group 1 compared to group 2 (319.76±45.7 vs 549.31±69.4, respectively, p=0.003). Proportion of patients with EPI was significantly higher in group 1 than group 2 (35.5% vs 12% p=0.042). There were no significant differences in terms of severity or the anatomic distribution of PS in patients with PS with EPI based on MRI (p=0.052, p=0.198, p=0.405)

 

Conclusion: Current study demonstrates that PS can cause EPI.

 

Cite this article as: Tahtacı M, Algın O, Karakan T, et al. Can pancreatic steatosis affect exocrine functions of pancreas? Turk J Gastroenterol 2018; 29: 588-94.

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