Turkish Journal of Gastroenterology
Pediatric Gastroenterology - Original Article

Bone mineral density and vitamin K status in children with celiac disease: Is there a relation?

1.

Department of Pediatric Gastroenterology, Erzurum Regional Training and Research Hospital, Erzurum, Turkey

2.

Department of Pediatris, Erzurum Regional Training and Research Hospital, Erzurum, Turkey

3.

Department of Pediatric Gastroenterology, Atatürk University School of Medicine, Erzurum, Turkey

4.

Department of Biochemistry, Atatürk University School of Medicine, Erzurum, Turkey

5.

Department of Pediatric Endocrinology, Erzurum Regional Training and Research Hospital, Erzurum, Turkey

Turk J Gastroenterol 2018; 29: 215-220
DOI: 10.5152/tjg.2018.17451
Read: 970 Downloads: 249 Published: 25 July 2019

Abstract

Background/Aims: To investigate bone mineral density (BMD) in children with celiac disease (CD) and to evaluate the association between vitamin K levels and osteoporosis.

 

Materials and Methods: Children with CD and age- and sex-matched healthy control subjects were prospectively included in the study. BMD was measured, and serum anti-tissue transglutaminase IgA, ferritin, folate, vitamin B12, 25-hydroxy vitamin D and K2, calcium, phosphate, alkaline phosphatase, and parathormone were assayed in all subjects.

 

Results: Overall, 72 patients (mean age 11.69±3 years, 59.7% female) and 30 healthy subjects (mean age 12.27±2.12 years, 63.3% female) were enrolled. The mean BMD Z score of the celiac group was significantly lower than that of the control group (−1.23±1.07 vs. −0.35±1.04, p=0.001). Vitamin D and K2 values did not differ significantly between the two groups (p>0.05). BMD was positively correlated with vitamin D (r=0.198, p=0.001) and negatively with PTH (r=−0.397, p=0.002).

 

Conclusion: The BMD of celiac patients was lower than that of the control subjects. There was no difference in terms of vitamin D and K2 levels between the two groups. Further studies investigating the level and effect of vitamin K on bone in CD are needed.

 

 

 

Cite this article as: Volkan B, Fettah A, İşlek A, Kara SS, Kurt N, Çayır A. Bone mineral density and vitamin K status in children with celiac disease: is there a relation? Turk J Gastroenterol 2018; 29: 215-20.

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