Turkish Journal of Gastroenterology
Liver - Original Article

Bone Marrow-Derived Stem Cells for Patients with Liver Cirrhosis: A Systematic Review and Meta-analysis

1.

Department of Infectious and Liver Disease, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, China

2.

Department of Otolaryngology, Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha, China

3.

Health Management Center, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510180, China

4.

Pharmac Department, The 421 Hospital of PLA, Guangzhou, China

5.

GCP Department, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, China

Turk J Gastroenterol 2021; 32: 896-906
DOI: 10.5152/tjg.2021.19694
Read: 1034 Downloads: 343 Published: 01 October 2021

Background: To date, studies have shown inconsistent results of treatment with bone marrow-derived stem cells (BMDSC) for patients with liver cirrhosis. This study aims to compare the efficacy and safety of BMDSC and standard therapy for liver cirrhosis.

Methods: Articles from PubMed, Embase, and the Cochrane library were searched from inception to April 2018. The index included Model for End-stage Liver Disease (MELD), alanine aminotransferase (ALT), albumin, total bilirubin (TBIL), prothrombin time (PT), Child–Pugh score, and all-cause mortality.

Results: A total of 9 studies with a total of 424 patients with liver cirrhosis were included in final meta-analysis. BMDSC therapy was associated with lower MELD within 3 months (P = .010), while it had no significant impact on MELD after 6 months (P = .074). There were no differences between BMDSC and standard therapy for ALT within 3 months (P = .336) and after 6 months (P = .379). BMDSC did not affect albumin level within 3 months (P = .196) and after 6 months (P = .840). BMDSC reduced the TBIL level within 3 months (P = .037) and was not associated with the TBIL level after 6 months (P = .914). There were no differences between BMDSC and standard therapy for PT within 3 months (P = .167) and after 6 months (P = .484). The Child–Pugh scores within 3 months (P = .342) and after 6 months (P = .133) were not associated with BMDSC treatment for liver cirrhosis patients. Finally, the BMDSC was not associated with the risk of all-cause mortality, as compared with standard therapy (P = .622).

Conclusions: BMDSC treatment for patients with liver cirrhosis could improve short-term MELD and TBIL, but not the risk of mortality, as compared with standard therapy.

Cite this article as: Ouyang S, Ouyang L, Li Y, Ye Y, Ban L. Bone marrow-derived stem cells for patients with liver cirrhosis: A systematic review and meta-analysis. Turk J Gastroenterol. 2021; 32(10): 896-906.

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