Turkish Journal of Gastroenterology
Basic & Translational - Original Article

Beneficial effect of synbiotics on experimental colon cancer in rats

1.

Department of Pathology, Metaxas Cancer Hospital, Piraeus, Greece

2.

Department of Surgery, University of Athens Laiko Hospital, Athens, Greece

3.

Experimental-Research Laboratory, ELPEN Pharma, Athens, Greece

4.

Inflammatory Bowel Disease Unit, IASO General Hospital, Athens, Greece

Turk J Gastroenterol 2018; 29: 494-501
DOI: 10.5152/tjg.2018.17469
Read: 451 Downloads: 191 Published: 25 July 2019

Abstract

Background/Aims: The aim of this study was to investigate the influence of a synbiotic preparation (a mixture of six probiotics and a prebiotic) on aberrant crypt foci (ACF) formation, dysplasia, inflammation, and colitis-like lesions in experimental colon cancer in rats.

 

Materials and Methods: Sixty male rats were categorized into three groups of 20 animals each. Group A was administered 1,2-dimethylydrazine, 15 mg/kg body weight (BW), once a week for 2 weeks. Group B was administered 1,2-dimethylydrazine at the same dose plus synbiotic, started after the second dose of carcinogen and lasted for 5 weeks. Group C was administered synbiotic plus carcinogen from the beginning of the experiment and lasted for 7 weeks. Animals were killed at the end of week 7.

 

Results: At the end of the experiment, the animals that received carcinogen plus the synbiotic had 100%, whereas the animals that received only carcinogen has 70% survival. Animals of groups B and C had significantly lower percentage of inflammation, colitis-like lesions, and ACF dysplasia than animals of group A, whereas those of group C had the least pathological lesions.

 

Conclusion: Synbiotics seem to protect against the appearance of preneoplastic colon lesions in rats. The results of this experimental study suggest that treatment with a synbiotic preparation exerts significant antimutagenic properties against the development of preneoplastic lesions in rats.

 

Cite this article as: Gavresea F, Vagianos C, Korontzi M, et al. Beneficial effect of synbiotics on experimental colon cancer in rats. Turk J Gastroenterol 2018; 29: 494-501.

 

 

Files
EISSN 2148-5607